Coronavirus disease 2019 (COVID-19): current status and future perspectives

H Li, SM Liu, XH Yu, SL Tang, CK Tang - International journal of …, 2020 - Elsevier
ABSTRACT Coronavirus disease 2019 (COVID-19) originated in the city of Wuhan, Hubei
Province, Central China, and has spread quickly to 72 countries to date. COVID-19 is …

[HTML][HTML] Immunomodulation by mesenchymal stem cells (MSCs): mechanisms of action of living, apoptotic, and dead MSCs

ARR Weiss, MH Dahlke - Frontiers in immunology, 2019 - frontiersin.org
Expectations on mesenchymal stem cell (MSC) treatment are high, especially in the fields of
sepsis, transplant medicine, and autoimmune diseases. Various pre-clinical studies have …

[HTML][HTML] Mesenchymal stromal cell apoptosis is required for their therapeutic function

SHM Pang, J D'Rozario, S Mendonca, T Bhuvan… - Nature …, 2021 - nature.com
Multipotent mesenchymal stromal cells (MSCs) ameliorate a wide range of diseases in
preclinical models, but the lack of clarity around their mechanisms of action has impeded …

Current status of potential therapeutic candidates for the COVID-19 crisis

J Zhang, B Xie, K Hashimoto - Brain, behavior, and immunity, 2020 - Elsevier
Abstract As of April 15, 2020, the ongoing coronavirus disease 2019 (COVID-2019)
pandemic has swept through 213 countries and infected more than 1,870,000 individuals …

[HTML][HTML] Pathogenesis of acute respiratory distress syndrome

LA Huppert, MA Matthay… - Seminars in respiratory and …, 2019 - thieme-connect.com
Acute respiratory distress syndrome (ARDS) is a syndrome of acute respiratory failure
caused by noncardiogenic pulmonary edema. Despite five decades of basic and clinical …

[HTML][HTML] Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine

FJ Vizoso, N Eiro, S Cid, J Schneider… - International journal of …, 2017 - mdpi.com
Earlier research primarily attributed the effects of mesenchymal stem cell (MSC) therapies to
their capacity for local engrafting and differentiating into multiple tissue types. However …

Mesenchymal stromal cells modulate macrophages in clinically relevant lung injury models by extracellular vesicle mitochondrial transfer

TJ Morrison, MV Jackson, EK Cunningham… - American journal of …, 2017 - atsjournals.org
Rationale: Acute respiratory distress syndrome (ARDS) remains a major cause of respiratory
failure in critically ill patients. Mesenchymal stromal cells (MSCs) are a promising candidate …

Exosomal miR-146a contributes to the enhanced therapeutic efficacy of interleukin-1β-primed mesenchymal stem cells against sepsis

Y Song, H Dou, X Li, X Zhao, Y Li, D Liu, J Ji, F Liu… - Stem …, 2017 - academic.oup.com
Improving the immunomodulatory efficacy of mesenchymal stem cells (MSCs) through
pretreatment with pro-inflammatory cytokines is an evolving field of investigation. However …

Acute lung injury

NT Mowery, WTH Terzian, AC Nelson - Current problems in surgery, 2020 - Elsevier
The clinical description that defines acute lung injury (ALI) has been around for more than
50 years. The clinical picture has carried many different definitions, but what was known as …

Mitochondrial transfer via tunneling nanotubes is an important mechanism by which mesenchymal stem cells enhance macrophage phagocytosis in the in vitro and in …

MV Jackson, TJ Morrison, DF Doherty, DF McAuley… - Stem …, 2016 - academic.oup.com
Mesenchymal stromal cells (MSC) have been reported to improve bacterial clearance in
preclinical models of Acute Respiratory Distress Syndrome (ARDS) and sepsis. The …