Long QT syndrome (LQTS) is an inherited primary arrhythmia syndrome that may present
with malignant arrhythmia and, rarely, risk of sudden death. The clinical symptoms include …

Wound healing is a sophisticated and orderly process of cellular interactions in which the
body restores tissue architecture and functionality following injury. Healing of chronic …

Opinion statement The study of inherited cardiac disorders is hampered by the lack of
suitable in vitro human cardiac disease models and relevant functional assays. A potential …

Human induced pluripotent stem cells (hIPSCs) have initiated a higher degree of successes
in disease modelling, preclinical evaluation of drug therapy and pharmaco-toxicological …

Induced pluripotent stem (iPS) cell technology offers an unprecedented opportunity to study
patient-specific disease. This biotechnology platform enables recapitulation of individualized …

This chapter discusses the Comprehensive In Vitro Proarrhythmia Assay (CiPA) initiative, an
integrated set of investigations that may lead to modifications of the nonclinical …

Ischemic heart disease is the leading cause of global mortality, and cardiovascular diseases
represent a major challenge for researchers because of the overall health complications …

Gaucher Disease (GD), the most common lysosomal storage disorder, is caused by
mutations in the GBA1 gene, which codes for the lysosomal enzyme β-glucocerebrosidase …