Prioritized research for the prevention, treatment, and reversal of chronic disease: recommendations from the lifestyle medicine research summit
Declining life expectancy and increasing all-cause mortality in the United States have been
associated with unhealthy behaviors, socioecological factors, and preventable disease. A …
associated with unhealthy behaviors, socioecological factors, and preventable disease. A …
Insights into the role of chemokines, damage-associated molecular patterns, and lymphocyte-derived mediators from computational models of trauma-induced …
Significance: Traumatic injury elicits a complex, dynamic, multidimensional inflammatory
response that is intertwined with complications such as multiple organ dysfunction and …
response that is intertwined with complications such as multiple organ dysfunction and …
Chitosan-Based Ciprofloxacin Extended Release Systems: Combined Synthetic and Pharmacological (In Vitro and In Vivo) Studies
AR Egorov, AV Kurliuk, VV Rubanik, AA Kirichuk… - Molecules, 2022 - mdpi.com
Ciprofloxacin is one of the most effective antibiotics, but it is characterized by a range of side
effects. Elaboration of drug-releasing systems which allow to diminish toxicity of …
effects. Elaboration of drug-releasing systems which allow to diminish toxicity of …
Toward a model-free feedback control synthesis for treating acute inflammation
An effective and patient-specific feedback control synthesis for inflammation resolution is still
an ongoing research area. A strategy consisting of manipulating a pro and anti-inflammatory …
an ongoing research area. A strategy consisting of manipulating a pro and anti-inflammatory …
A computational, tissue-realistic model of pressure ulcer formation in individuals with spinal cord injury
C Ziraldo, A Solovyev, A Allegretti… - PLoS computational …, 2015 - journals.plos.org
People with spinal cord injury (SCI) are predisposed to pressure ulcers (PU). PU remain a
significant burden in cost of care and quality of life despite improved mechanistic …
significant burden in cost of care and quality of life despite improved mechanistic …
Individual-specific principal component analysis of circulating inflammatory mediators predicts early organ dysfunction in trauma patients
RA Namas, K Almahmoud, Q Mi, A Ghuma… - Journal of critical …, 2016 - Elsevier
Purpose We hypothesized that early inflammation can drive, or impact, later multiple organ
dysfunction syndrome (MODS), that patient-specific principal component analysis (PCA) of …
dysfunction syndrome (MODS), that patient-specific principal component analysis (PCA) of …
Preparing for the next Pandemic: Simulation-based Deep Reinforcement Learning to discover and test multimodal control of systemic inflammation using repurposed …
C Cockrell, D Larie, G An - Frontiers in Immunology, 2022 - frontiersin.org
Background Preparation to address the critical gap in a future pandemic between non-
pharmacological measures and the deployment of new drugs/vaccines requires addressing …
pharmacological measures and the deployment of new drugs/vaccines requires addressing …
A systems engineering perspective on homeostasis and disease
Engineered systems are coupled networks of interacting sub-systems, whose dynamics are
constrained to requirements of robustness and flexibility. They have evolved by design to …
constrained to requirements of robustness and flexibility. They have evolved by design to …
Augmenting Surgery via Multi-scale Modeling and Translational Systems Biology in the Era of Precision Medicine: A Multidisciplinary Perspective
In this era of tremendous technological capabilities and increased focus on improving
clinical outcomes, decreasing costs, and increasing precision, there is a need for a more …
clinical outcomes, decreasing costs, and increasing precision, there is a need for a more …
The effects of tacrolimus on tissue-specific, protein-level inflammatory networks in vascularized composite allotransplantation
Systems-level insights into inflammatory events after vascularized composite
allotransplantation (VCA) are critical to the success of immunomodulatory strategies of these …
allotransplantation (VCA) are critical to the success of immunomodulatory strategies of these …