Developmental programming of obesity and insulin resistance: does mitochondrial dysfunction in oocytes play a role?
Insulin resistance is a key defect associated with obesity, type 2 diabetes and other
metabolic diseases. While a number of factors have been suggested to cause defects in …
metabolic diseases. While a number of factors have been suggested to cause defects in …
Effect of exercise training on insulin sensitivity, mitochondria and computed tomography muscle attenuation in overweight women with and without polycystic ovary …
Aims/hypothesis Polycystic ovary syndrome (PCOS) is an insulin resistant (IR) state.
Increased skeletal muscle lipid content and impaired mitochondrial biogenesis have been …
Increased skeletal muscle lipid content and impaired mitochondrial biogenesis have been …
Obesity, adipogenesis and insulin resistance
MR Pérez, G Medina-Gómez - Endocrinología y Nutrición (English Edition), 2011 - Elsevier
Insulin resistance precedes the development of type 2 diabetes mellitus and is also a
common denominator in the so-called metabolic syndrome. Although the cause of insulin …
common denominator in the so-called metabolic syndrome. Although the cause of insulin …
Insulin resistance and fuel homeostasis: the role of AMP‐activated protein kinase
BD Hegarty, N Turner, GJ Cooney… - Acta …, 2009 - Wiley Online Library
The worldwide prevalence of type 2 diabetes (T2D) and related disorders of the metabolic
syndrome (MS) has reached epidemic proportions. Insulin resistance (IR) is a major …
syndrome (MS) has reached epidemic proportions. Insulin resistance (IR) is a major …
Mitochondrial DNA copy number in peripheral blood in polycystic ovary syndrome
SH Lee, DJ Chung, HS Lee, TJ Kim, MH Kim, HJ Jeong… - Metabolism, 2011 - Elsevier
Polycystic ovary syndrome (PCOS) is associated with insulin resistance and various
metabolic diseases; and recently, elevated oxidative stress has been detected in PCOS …
metabolic diseases; and recently, elevated oxidative stress has been detected in PCOS …
[HTML][HTML] Hypothalamic mitochondrial dysfunction as a target in obesity and metabolic disease
J Cunarro, S Casado, J Lugilde, S Tovar - Frontiers in endocrinology, 2018 - frontiersin.org
Mitochondria are important organelles for the adaptation to energy demand that play a
central role in bioenergetics metabolism. The mitochondrial architecture and mitochondrial …
central role in bioenergetics metabolism. The mitochondrial architecture and mitochondrial …
Are sirtuin deacylase enzymes important modulators of mitochondrial energy metabolism?
Background In recent years, reversible lysine acylation of proteins has emerged as a major
post-translational modification across the cell, and importantly has been shown to regulate …
post-translational modification across the cell, and importantly has been shown to regulate …
Potential candidates from marine and terrestrial resources targeting mitochondrial inhibition: Insights from the molecular approach
Mitochondria are the target sites for multiple disease manifestations, for which it is appealing
to researchers' attention for advanced pharmacological interventions. Mitochondrial …
to researchers' attention for advanced pharmacological interventions. Mitochondrial …
(–)-Epigallocatechin-3-gallate attenuated myocardial mitochondrial dysfunction and autophagy in diabetic Goto–Kakizaki rats
Type 2 diabetes mellitus (T2DM) is a risk factor for heart disease. However, the mechanisms
of T2DM involvement in cardiac complications are still unclear. In the present study, we …
of T2DM involvement in cardiac complications are still unclear. In the present study, we …
Amelioration of lipid-induced insulin resistance in rat skeletal muscle by overexpression of Pgc-1β involves reductions in long-chain acyl-CoA levels and oxidative …
LE Wright, AE Brandon, AJ Hoy, GB Forsberg… - Diabetologia, 2011 - Springer
Abstract Aims/Hypothesis To determine if acute overexpression of peroxisome proliferator-
activated receptor, gamma, coactivator 1 beta (Pgc-1β [also known as Ppargc1b]) in skeletal …
activated receptor, gamma, coactivator 1 beta (Pgc-1β [also known as Ppargc1b]) in skeletal …