Role and clinical significance of lymphocyte mitochondrial dysfunction in type 2 diabetes mellitus

S Khan, GV Raghuram, A Bhargava, N Pathak… - Translational …, 2011 - Elsevier
Lymphocyte homeostasis in type 2 diabetes mellitus (T2DM) is associated with increased
susceptibility to infections. Mitochondrial oxidative stress is implicated primarily in the …

Advances in PCOS Pathogenesis and progression—mitochondrial mutations and dysfunction

IR Ilie - Advances in clinical chemistry, 2018 - Elsevier
Polycystic ovary syndrome (PCOS) is a common female endocrine disorder, which still
remains largely unsolved in terms of etiology and pathogenesis despite important advances …

[HTML][HTML] Resistant dextrin improves high-fat-high-fructose diet induced insulin resistance

F Hu, Y Niu, X Xu, Q Hu, Q Su, H Zhang - Nutrition & Metabolism, 2020 - Springer
Background Insulin resistance is an important defect associated with obesity and type 2
diabetes mellitus. Many studies have been reported that dietary fiber exerts beneficial …

A possible link between hepatic mitochondrial dysfunction and diet-induced insulin resistance

R Crescenzo, F Bianco, A Mazzoli, A Giacco… - European journal of …, 2016 - Springer
Background Mitochondria are the main cellular sites devoted to ATP production and lipid
oxidation. Therefore, the mitochondrial dysfunction could be an important determinant of …

[HTML][HTML] The role of insulin resistance in diabetic neuropathy in Koreans with type 2 diabetes mellitus: a 6-year follow-up study

YN Cho, KO Lee, J Jeong, HJ Park, SM Kim… - Yonsei medical …, 2014 - ncbi.nlm.nih.gov
Purpose We previously reported that insulin resistance, low high-density lipoprotein (HDL)
cholesterol, and glycaemic exposure Index are independently associated with peripheral …

Impaired exercise-induced mitochondrial biogenesis in the obese Zucker rat, despite PGC-1α induction, is due to compromised mitochondrial translation elongation

NP Greene, MI Nilsson… - American Journal …, 2014 - journals.physiology.org
Previously, we demonstrated that high-volume resistance exercise stimulates mitochondrial
protein synthesis (a measure of mitochondrial biogenesis) in lean but not obese Zucker rats …

Targeting insulin for Alzheimer's disease: mechanisms, status and potential directions

JH Lee, JB Jahrling, L Denner… - Journal of Alzheimer's …, 2018 - content.iospress.com
Insulin resistance can occur when the body is unable to respond to insulin even in excess. In
the brain, insulin manages glucose metabolism in regions such as the hippocampus and …

[HTML][HTML] Effect of vitamin D3 on mitochondrial biogenesis in granulosa cells derived from polycystic ovary syndrome

Z Safaei, S Bakhshalizadeh… - … Journal of Fertility & …, 2020 - ncbi.nlm.nih.gov
Background Polycystic ovary syndrome (PCOS) is an endocrine disorder diagnosed by
anovulation hyperandro-genism. Hyperandrogenism increases apoptosis, which will …

Increased Protein Tyrosine Phosphatase 1B (PTP 1B) Activity and Cardiac Insulin Resistance Precede Mitochondrial and Contractile Dysfunction in Pressure …

TD Nguyen, M Schwarzer, A Schrepper… - Journal of the …, 2018 - Am Heart Assoc
Background Insulin resistance in diabetes mellitus has been associated with mitochondrial
dysfunction. Defects at the level of mitochondria are also characteristic of heart failure. We …

Targeting tissue-specific metabolic signaling pathways in aging: the promise and limitations

F Hu, F Liu - Protein & cell, 2014 - academic.oup.com
It has been well established that most of the age-related diseases such as insulin resistance,
type 2 diabetes, hypertension, cardiovascular disease, osteoporosis, and atherosclerosis …