Importance Acute respiratory distress syndrome (ARDS) is a life-threatening form of
respiratory failure that affects approximately 200 000 patients each year in the United States …

The monolayer of endothelial cells lining the vessel wall forms a semipermeable barrier (in
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …

Background The efficacy of simvastatin in critically ill patients with coronavirus disease 2019
(Covid-19) is unclear. Methods In an ongoing international, multifactorial, adaptive platform …

Statins are lipid-lowering therapeutics with favorable anti-inflammatory profiles and have
been proposed as an adjunct therapy for COVID-19. However, statins may increase the risk …

Purpose Using latent class analysis (LCA), we have consistently identified two distinct
subphenotypes in four randomized controlled trial cohorts of ARDS. One subphenotype has …

Background Studies in animals and in vitro and phase 2 studies in humans suggest that
statins may be beneficial in the treatment of the acute respiratory distress syndrome (ARDS) …

Background Acute respiratory distress syndrome (ARDS) is a life‐threatening condition
caused by direct or indirect injury to the lungs. Despite improvements in clinical …

BACKGROUND In the acute respiratory distress syndrome (ARDS), inflammation in the
lungs and other organs can cause life-threatening organ failure. Inhibitors of 3-hydroxy-3 …

BackgroundCross-sectional studies support an association between depression and
inflammatory markers. However, little is known of their relationship in the context of …

In this review we summarize recent major advances in our understanding on the molecular
mechanisms, mediators, and biomarkers of acute lung injury (ALI) and alveolar-capillary …