The prefrontal cortex (PFC) is not only important in executive functions, but also pain
processing. The latter is dependent on its connections to other areas of the cerebral …

Chronic pain is a condition in which pain progresses from an acute to chronic state and
persists beyond the healing process. Chronic pain impairs function and decreases patients' …

Cognition is defined as the brain's ability to acquire, process, store, and retrieve information.
Pain has been described as an unpleasant sensory or emotional experience, and for …

Neuropathic pain can be a debilitating condition with both sensory and affective
components, the underlying brain circuitry of which remains poorly understood. In the …

Chronic, pathological pain remains a global health problem and a challenge to basic and
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …

Chronic pain is one of the most prevalent health problems in our modern world, with millions
of people debilitated by conditions such as back pain, headache and arthritis. To address …

Abstract See Tracey (doi: 10.1093/brain/aww147) for a scientific commentary on this article.
Mechanisms of chronic pain remain poorly understood. We tracked brain properties in …

Chronic pain states are highly prevalent and yet poorly controlled by currently available
analgesics, representing an enormous clinical, societal, and economic burden. Existing pain …

A limbic brain area, the amygdala plays a key role in emotional responses and affective
states and disorders such as learned fear, anxiety, and depression. The amygdala has also …

Abstract Objective and Method: Research on emotion and pain has burgeoned. We review
the last decade's literature, focusing on links between emotional processes and persistent …