[HTML][HTML] Regulated cell death (RCD) in cancer: key pathways and targeted therapies

F Peng, M Liao, R Qin, S Zhu, C Peng, L Fu… - Signal transduction and …, 2022 - nature.com
Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …

[HTML][HTML] MAPK/ERK signaling pathway in hepatocellular carcinoma

H Moon, SW Ro - Cancers, 2021 - mdpi.com
Simple Summary The mitogen-activated protein kinase/extracellular signal-regulated kinase
(MAPK/ERK) signaling pathway is frequently activated in liver cancer, which is one of the …

Highly retina-permeating and long-acting resveratrol/metformin nanotherapeutics for enhanced treatment of macular degeneration

DD Nguyen, LJ Luo, CJ Yang, JY Lai - ACS nano, 2022 - ACS Publications
The development of therapeutics for effective treatments of retinal diseases is significantly
constrained by various biological barriers. We herein report a nanomedicine strategy to …

Cellular aging beyond cellular senescence: Markers of senescence prior to cell cycle arrest in vitro and in vivo

M Ogrodnik - Aging cell, 2021 - Wiley Online Library
The field of research on cellular senescence experienced a rapid expansion from being
primarily focused on in vitro aspects of aging to the vast territories of animal and clinical …

[HTML][HTML] The role of oxidative stress in ovarian aging: a review

F Yan, Q Zhao, Y Li, Z Zheng, X Kong, C Shu… - Journal of ovarian …, 2022 - Springer
Ovarian aging refers to the process by which ovarian function declines until eventual failure.
The pathogenesis of ovarian aging is complex and diverse; oxidative stress (OS) is …

The angiotensin AT2 receptor: from a binding site to a novel therapeutic target

UM Steckelings, RE Widdop, ED Sturrock… - Pharmacological …, 2022 - ASPET
Discovered more than 30 years ago, the angiotensin AT2 receptor (AT2R) has evolved from
a binding site with unknown function to a firmly established major effector within the …

Apoptosis in Alzheimer's disease: insight into the signaling pathways and therapeutic avenues

S Kumari, R Dhapola, DHK Reddy - Apoptosis, 2023 - Springer
Alzheimer's disease (AD) is characterized by the accumulation of hyperphosphorylated tau
and amyloid-β (Aβ) protein resulting in synaptic loss and apoptosis. Aβ and tau deposition …

[HTML][HTML] Anticancer activity of propolis and its compounds

E Forma, M Bryś - Nutrients, 2021 - mdpi.com
Propolis is a natural material that honey bees (Apis mellifera) produce from various
botanical sources. The therapeutic activity of propolis, including antibacterial, antifungal, and …

The signaling pathways and targets of traditional Chinese medicine and natural medicine in triple-negative breast cancer

Z Yang, Q Zhang, L Yu, J Zhu, Y Cao, X Gao - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Triple-negative breast cancer (TNBC) has a poorer
prognosis than other subtypes due to its strong invasion and higher risk of distant …

Mechanically reinforced injectable bioactive nanocomposite hydrogels for in-situ bone regeneration

X Yu, X Wang, D Li, R Sheng, Y Qian, R Zhu… - Chemical Engineering …, 2022 - Elsevier
Gelatin-methacryloyl (GelMA) has received extensive attention in tissue engineering
because of its low antigenicity, suitable biodegradability, and similarity to ECM. However, it …