Hesperidin protects against the chlorpyrifos‐induced chronic hepato‐renal toxicity in rats associated with oxidative stress, inflammation, apoptosis, autophagy, and up …

S Küçükler, S Çomaklı, S Özdemir… - Environmental …, 2021 - Wiley Online Library
In this study, we investigated the effects of hesperidin (HSP) on oxidants/antioxidants status,
inflammation, apoptotic, and autophagic activity in hepato‐renal toxicity induced by chronic …

The intestinal fate of citrus flavanones and their effects on gastrointestinal health

Y Stevens, EV Rymenant, C Grootaert, JV Camp… - Nutrients, 2019 - mdpi.com
Citrus flavanones, with hesperidin and naringin as the most abundant representatives, have
various beneficial effects, including anti-oxidative and anti-inflammatory activities. Evidence …

Interactions between dietary flavonoids and the gut microbiome: a comprehensive review

MH Baky, M Elshahed, L Wessjohann… - British Journal of …, 2022 - cambridge.org
Flavonoids are natural polyphenol secondary metabolites that are widely produced in
planta. Flavonoids are ubiquities in human dietary intake and exhibit a myriad of health …

The flavonoid-rich Quzhou Fructus Aurantii extract modulates gut microbiota and prevents obesity in high-fat diet-fed mice

Y Bai, S Wang, X Wang, Y Weng, X Fan, H Sheng… - Nutrition & …, 2019 - nature.com
Background Flavonoids are reported to modulate the composition of gut microbiota, which
play an important role in preventing obesity and associated metabolic diseases. In this …

Enzymatic metabolism of flavonoids by gut microbiota and its impact on gastrointestinal cancer

RK Al-Ishaq, A Liskova, P Kubatka, D Büsselberg - Cancers, 2021 - mdpi.com
Simple Summary Flavonoid's consumption is reported to impact GI cancer progression
positively. As 90% of flavonoids consumed, undergo metabolism and conversion by the …

Dietary flavonoids and gut microbiota interaction: A focus on animal and human studies to maximize their health benefits

L Yang, Y Gao, MA Farag, J Gong, Q Su, H Cao… - Food …, 2023 - Wiley Online Library
Flavonoids are phytochemicals that widely exist in plants, fruits, and vegetables and have a
variety of activities. However, due to their complex structure, it is often rarely absorbed into …

Effects of several flavonoids on human gut microbiota and its metabolism by in vitro simulated fermentation

L Pan, H Ye, X Pi, W Liu, Z Wang, Y Zhang… - Frontiers in …, 2023 - frontiersin.org
Introduction Flavonoids have antiviral, antitumor, anti-inflammatory, and other biological
activities. They have high market value and are widely used in food and medicine fields …

[HTML][HTML] Polyphenols synergistic drugs to ameliorate non-alcoholic fatty liver disease via signal pathway and gut microbiota: A review

H Li, J Liang, M Han, Z Gao - Journal of Advanced Research, 2024 - Elsevier
Background Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease
with an increasing incidence worldwide. Single drug therapy may have toxic side effects and …

Effect of hesperidin supplementation on liver metabolomics and gut microbiota in a high-fat diet-induced NAFLD mice model

X Li, Y Yao, Y Wang, L Hua, M Wu, F Chen… - Journal of Agricultural …, 2022 - ACS Publications
The present study investigated the mechanism underlying the impact of hesperidin (HES) on
nonalcoholic fatty liver (NAFLD). C57BL/6J male mice were administered a low-fat diet, high …

Prevention and treatment of chronic heart failure through traditional Chinese medicine: role of the gut microbiota

Q Jia, L Wang, X Zhang, Y Ding, H Li, Y Yang… - Pharmacological …, 2020 - Elsevier
In recent years, although the concept and means of modern treatment of chronic heart failure
(CHF) are continually improving, the readmission rate and mortality rate are still high. At …