Circuit organization of the rodent medial prefrontal cortex
PG Anastasiades, AG Carter - Trends in neurosciences, 2021 - cell.com
The prefrontal cortex (PFC) orchestrates higher brain function and becomes disrupted in
many mental health disorders. The rodent medial PFC (mPFC) possesses an enormous …
many mental health disorders. The rodent medial PFC (mPFC) possesses an enormous …
Role of the prefrontal cortex in pain processing
WY Ong, CS Stohler, DR Herr - Molecular neurobiology, 2019 - Springer
The prefrontal cortex (PFC) is not only important in executive functions, but also pain
processing. The latter is dependent on its connections to other areas of the cerebral …
processing. The latter is dependent on its connections to other areas of the cerebral …
A neuronal circuit for activating descending modulation of neuropathic pain
J Huang, VM Gadotti, L Chen, IA Souza, S Huang… - Nature …, 2019 - nature.com
Neuropathic pain can be a debilitating condition with both sensory and affective
components, the underlying brain circuitry of which remains poorly understood. In the …
components, the underlying brain circuitry of which remains poorly understood. In the …
[HTML][HTML] Cellular circuits in the brain and their modulation in acute and chronic pain
Chronic, pathological pain remains a global health problem and a challenge to basic and
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …
Neocortical circuits in pain and pain relief
LL Tan, R Kuner - Nature Reviews Neuroscience, 2021 - nature.com
The sensory, associative and limbic neocortical structures play a critical role in shaping
incoming noxious inputs to generate variable pain perceptions. Technological advances in …
incoming noxious inputs to generate variable pain perceptions. Technological advances in …
The medial prefrontal cortex as a central hub for mental comorbidities associated with chronic pain
KK Kummer, M Mitrić, T Kalpachidou… - International journal of …, 2020 - mdpi.com
Chronic pain patients frequently develop and suffer from mental comorbidities such as
depressive mood, impaired cognition, and other significant constraints of daily life, which …
depressive mood, impaired cognition, and other significant constraints of daily life, which …
[HTML][HTML] A nociceptive neuronal ensemble in the dorsomedial prefrontal cortex underlies pain chronicity
Pain chronicity involves unpleasant experience in both somatosensory and affective
aspects, accompanied with the prefrontal cortex (PFC) neuroplastic alterations. However …
aspects, accompanied with the prefrontal cortex (PFC) neuroplastic alterations. However …
Mapping cortical integration of sensory and affective pain pathways
Pain is an integrated sensory and affective experience. Cortical mechanisms of sensory and
affective integration, however, remain poorly defined. Here, we investigate the projection …
affective integration, however, remain poorly defined. Here, we investigate the projection …
Oxytocin promotes prefrontal population activity via the PVN-PFC pathway to regulate pain
Y Liu, A Li, C Bair-Marshall, H Xu, HJ Jee, E Zhu… - Neuron, 2023 - cell.com
Neurons in the prefrontal cortex (PFC) can provide top-down regulation of sensory-affective
experiences such as pain. Bottom-up modulation of sensory coding in the PFC, however …
experiences such as pain. Bottom-up modulation of sensory coding in the PFC, however …
Closed-loop stimulation using a multiregion brain-machine interface has analgesic effects in rodents
G Sun, F Zeng, M McCartin, Q Zhang, H Xu… - Science translational …, 2022 - science.org
Effective treatments for chronic pain remain limited. Conceptually, a closed-loop neural
interface combining sensory signal detection with therapeutic delivery could produce timely …
interface combining sensory signal detection with therapeutic delivery could produce timely …