The prefrontal cortex (PFC) orchestrates higher brain function and becomes disrupted in
many mental health disorders. The rodent medial PFC (mPFC) possesses an enormous …

The prefrontal cortex (PFC) is not only important in executive functions, but also pain
processing. The latter is dependent on its connections to other areas of the cerebral …

Neuropathic pain can be a debilitating condition with both sensory and affective
components, the underlying brain circuitry of which remains poorly understood. In the …

Chronic, pathological pain remains a global health problem and a challenge to basic and
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …

The sensory, associative and limbic neocortical structures play a critical role in shaping
incoming noxious inputs to generate variable pain perceptions. Technological advances in …

Chronic pain patients frequently develop and suffer from mental comorbidities such as
depressive mood, impaired cognition, and other significant constraints of daily life, which …

Pain chronicity involves unpleasant experience in both somatosensory and affective
aspects, accompanied with the prefrontal cortex (PFC) neuroplastic alterations. However …

Pain is an integrated sensory and affective experience. Cortical mechanisms of sensory and
affective integration, however, remain poorly defined. Here, we investigate the projection …

Neurons in the prefrontal cortex (PFC) can provide top-down regulation of sensory-affective
experiences such as pain. Bottom-up modulation of sensory coding in the PFC, however …

Effective treatments for chronic pain remain limited. Conceptually, a closed-loop neural
interface combining sensory signal detection with therapeutic delivery could produce timely …