Hypoxia is one of the most common and severe challenges to the maintenance of
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …

Introduction The main objective was to carry out a global DNA methylation analysis in a
population with gender incongruence before gender-affirming hormone treatment (GAHT), in …

Early-life exposure to toxicants could affect health outcomes in adulthood. We determined
the effects of early-life exposure to the organophosphorus flame-retardant tris (1, 3-dichloro …

As a pervasive neurodevelopmental disease, autism spectrum disorder (ASD) is caused by
both hereditary and environmental elements. Research has demonstrated the functions of …

Perimenopause marks initiation of female reproductive senescence. Age of onset is only
47% heritable suggesting that additional factors other than inheritance regulate this …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder associated with cognitive
impairment and later dementia among the elderly. Mounting evidence shows that adverse …

Background Fetal hypoxia causes vital, systemic, developmental malformations in the fetus,
particularly in the brain, and increases the risk of diseases in later life. We previously …

Maternal e-cigarette (e-cig) exposure is a pressing perinatal health concern. Emerging
evidence reveals its potential adverse impacts on brain development in offspring, yet the …

Maternal tobacco use in pregnancy increases the risk of neurodevelopmental disorders and
neurobehavioral deficits in postnatal life. The present study tested the hypothesis that …

Major Depressive Disorder (MDD) is a widespread debilitating neuropsychiatric disorder.
While a broad range of drugs to treat MDD are available, a large portion of the patients fail to …