Impact of intermittent fasting on health and disease processes
Humans in modern societies typically consume food at least three times daily, while
laboratory animals are fed ad libitum. Overconsumption of food with such eating patterns …
laboratory animals are fed ad libitum. Overconsumption of food with such eating patterns …
Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs
Abstract According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …
[HTML][HTML] Functions and dysfunctions of nitric oxide in brain
P Picón-Pagès, J Garcia-Buendia, FJ Munoz - Biochimica et Biophysica …, 2019 - Elsevier
Nitric oxide (NO) works as a retrograde neurotransmitter in synapses, allows the brain blood
flow and also has important roles in intracellular signaling in neurons from the regulation of …
flow and also has important roles in intracellular signaling in neurons from the regulation of …
[HTML][HTML] Amyloid beta: structure, biology and structure-based therapeutic development
Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a
transmembrane protein, amyloid precursor protein (APP), by β-and γ-secretases. Aβ …
transmembrane protein, amyloid precursor protein (APP), by β-and γ-secretases. Aβ …
[HTML][HTML] The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives
Ten years ago we first proposed the Alzheimer's disease (AD) mitochondrial cascade
hypothesis. This hypothesis maintains that gene inheritance defines an individual's baseline …
hypothesis. This hypothesis maintains that gene inheritance defines an individual's baseline …
Oxidative stress and the pathogenesis of Alzheimer′ s disease
Y Zhao, B Zhao - Oxidative medicine and cellular longevity, 2013 - Wiley Online Library
Alzheimer′ s disease (AD) is the most common neurodegenerative disease that causes
dementia in the elderly. Patients with AD suffer a gradual deterioration of memory and other …
dementia in the elderly. Patients with AD suffer a gradual deterioration of memory and other …
Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy
Y Lee, S El Andaloussi, MJA Wood - Human molecular genetics, 2012 - academic.oup.com
Exosomes and microvesicles are extracellular nanovesicles released by most but not all
cells. They are specifically equipped to mediate intercellular communication via the transfer …
cells. They are specifically equipped to mediate intercellular communication via the transfer …
Amyloid β-Peptide (1–42)-Induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression
DA Butterfield, AM Swomley… - Antioxidants & redox …, 2013 - liebertpub.com
Significance: Alzheimer disease (AD) is an age-related neurodegenerative disease. AD is
characterized by progressive cognitive impairment. One of the main histopathological …
characterized by progressive cognitive impairment. One of the main histopathological …
An overview of APP processing enzymes and products
VW Chow, MP Mattson, PC Wong… - Neuromolecular …, 2010 - Springer
The generation of amyloid β-peptide (Aβ) by enzymatic cleavages of the β-amyloid
precursor protein (APP) has been at the center of Alzheimer's disease (AD) research. While …
precursor protein (APP) has been at the center of Alzheimer's disease (AD) research. While …
Pathways towards and away from Alzheimer's disease
MP Mattson - Nature, 2004 - nature.com
Slowly but surely, Alzheimer's disease (AD) patients lose their memory and their cognitive
abilities, and even their personalities may change dramatically. These changes are due to …
abilities, and even their personalities may change dramatically. These changes are due to …