Updated insights into the T cell-mediated immune response against SARS-CoV-2: a step towards efficient and reliable vaccines
M Dhawan, AA Rabaan, MMA Fawarah, SA Almuthree… - Vaccines, 2023 - mdpi.com
The emergence of novel variants of SARS-CoV-2 and their abilities to evade the immune
response elicited through presently available vaccination makes it essential to recognize the …
response elicited through presently available vaccination makes it essential to recognize the …
Reprogramming of cancer-associated fibroblasts combined with immune checkpoint inhibitors: A potential therapeutic strategy for cancers
M Li, B Wu, L Li, C Lv, Y Tian - … et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Activated fibroblasts, namely cancer-associated fibroblasts (CAFs), are highly
heterogeneous in phenotypes, functions, and origins. CAFs originated from varieties of cell …
heterogeneous in phenotypes, functions, and origins. CAFs originated from varieties of cell …
Spatial relationships in the tumor microenvironment demonstrate association with pathologic response to Neoadjuvant Chemoimmunotherapy in muscle-invasive …
W Beckabir, SE Wobker, JS Damrauer, B Midkiff… - European urology, 2024 - Elsevier
Background Platinum-based neoadjuvant chemotherapy (NAC) is standard for patients with
muscle-invasive bladder cancer (MIBC). Pathologic response (complete: ypT0N0 and …
muscle-invasive bladder cancer (MIBC). Pathologic response (complete: ypT0N0 and …
Immune checkpoint blockade resistance in lung cancer: emerging mechanisms and therapeutic opportunities
JM Konen, H Wu, DL Gibbons - Trends in Pharmacological Sciences, 2024 - cell.com
Immune checkpoint blockade (ICB) therapy works by inhibiting suppressive checkpoints that
become upregulated after T cell activation, like PD-1/PD-L1 and CTLA-4. While the initial …
become upregulated after T cell activation, like PD-1/PD-L1 and CTLA-4. While the initial …
The role of immunosuppressive myofibroblasts in the aging process and age-related diseases
A Salminen - Journal of Molecular Medicine, 2023 - Springer
Tissue-resident fibroblasts are mesenchymal cells which control the structural integrity of the
extracellular matrix (ECM). Fibroblasts possess a remarkable plasticity to allow them to …
extracellular matrix (ECM). Fibroblasts possess a remarkable plasticity to allow them to …
Immune-related adverse events and immune checkpoint inhibitors: a focus on neurotoxicity and clinical management
R Ruggiero, R Di Napoli, N Balzano… - Expert Review of …, 2023 - Taylor & Francis
ABSTRACT Introduction Immune checkpoint inhibitors (ICIs) represent an innovative
therapeutic approach of oncologic diseases. In Europe, this therapeutic class currently …
therapeutic approach of oncologic diseases. In Europe, this therapeutic class currently …
[HTML][HTML] Crosstalk between fibroblasts and T cells in immune networks
B Lee, SH Lee, K Shin - Frontiers in Immunology, 2023 - frontiersin.org
Fibroblasts are primarily considered as cells that support organ structures and are currently
receiving attention for their roles in regulating immune responses in health and disease …
receiving attention for their roles in regulating immune responses in health and disease …
Crosstalk between colorectal cancer cells and cancer-associated fibroblasts in the tumor microenvironment mediated by exosomal noncoding RNAs
S Sun, Y Zhang, Y Li, L Wei - Frontiers in Immunology, 2023 - frontiersin.org
Colorectal cancer (CRC) is a common malignant tumor of the digestive system, and its
morbidity rates are increasing worldwide. Cancer-associated fibroblasts (CAFs), as part of …
morbidity rates are increasing worldwide. Cancer-associated fibroblasts (CAFs), as part of …
Cancer-associated fibroblasts: a versatile mediator in tumor progression, metastasis, and targeted therapy
T Guo, J Xu - Cancer and Metastasis Reviews, 2024 - Springer
Tumor microenvironment (TME) has been demonstrated to play a significant role in tumor
initiation, progression, and metastasis. Cancer-associated fibroblasts (CAFs) are the major …
initiation, progression, and metastasis. Cancer-associated fibroblasts (CAFs) are the major …
Evaluation of tumor response to immune checkpoint inhibitors by a 3D immunotumoroid model
A Pezeshki, JC Cheville, AB Florio… - Frontiers in …, 2024 - frontiersin.org
Background Only 20 percent of renal and bladder cancer patients will show a significant
response to immune checkpoint inhibitor (ICI) therapy, and no test currently available …
response to immune checkpoint inhibitor (ICI) therapy, and no test currently available …