Spurred by advances in processing power, memory, storage, and an unprecedented wealth
of data, computers are being asked to tackle increasingly complex learning tasks, often with …

The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Genome-wide association studies (GWAS) have revealed thousands of genetic loci that
underpin the complex biology of many human traits. However, the strength of GWAS–the …

Background: Filamin C (encoded by the FLNC gene) is essential for sarcomere attachment
to the plasmatic membrane. FLNC mutations have been associated with myofibrillar …

Dilated cardiomyopathy (DCM) is an umbrella term entailing a wide variety of genetic and
non-genetic etiologies, leading to left ventricular systolic dysfunction and dilatation, not …

Filamin C (FLNC) variants are associated with cardiac and muscular phenotypes. Originally,
FLNC variants were described in myofibrillar myopathy (MFM) patients. Later, high …

Objectives: The purpose of this study was to assess the phenotype of Filamin C (FLNC)
truncating variants in dilated cardiomyopathy (DCM) and understand the mechanism …

Filamin C (FLNC) is one of three filamin proteins (Filamin A (FLNA), Filamin B (FLNB), and
FLNC) that cross-link actin filaments and interact with numerous binding partners. FLNC …

As personal genome sequencing becomes a reality, understanding the effects of genetic
variants on phenotype—particularly the impact of germline variants on disease risk and the …

A genetic etiology has been identified in 30% to 40% of dilated cardiomyopathy (DCM)
patients, yet only 50% of these cases are associated with a known causative gene variant …