Interleukins and ischemic stroke

H Zhu, S Hu, Y Li, Y Sun, X Xiong, X Hu… - Frontiers in …, 2022 - frontiersin.org
Ischemic stroke after cerebral artery occlusion is one of the major causes of chronic disability
worldwide. Interleukins (ILs) play a bidirectional role in ischemic stroke through information …

[HTML][HTML] NLRP3 inflammasome: The rising star in cardiovascular diseases

Y Zheng, L Xu, N Dong, F Li - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Cardiovascular diseases (CVDs) are the prevalent cause of mortality around the world.
Activation of inflammasome contributes to the pathological progression of cardiovascular …

Accelerated vascular aging in chronic kidney disease: the potential for novel therapies

S Hobson, S Arefin, A Witasp, L Hernandez… - Circulation …, 2023 - Am Heart Assoc
The pathophysiology of vascular disease is linked to accelerated biological aging and a
combination of genetic, lifestyle, biological, and environmental risk factors. Within the …

β-Hydroxybutyrate alleviates pyroptosis in MPP+/MPTP-induced Parkinson's disease models via inhibiting STAT3/NLRP3/GSDMD pathway

Z Jiang, X Yin, M Wang, Y Wang, F Li, Y Gao… - International …, 2022 - Elsevier
Background Parkinson's disease (PD) is a common neurodegenerative disease
characterized by motor symptoms and non-motor symptoms, and affects millions of people …

The pivotal role of JAK/STAT and IRS/PI3K signaling pathways in neurodegenerative diseases: Mechanistic approaches to polyphenols and alkaloids

L Kooshki, SN Zarneshan, S Fakhri, SZ Moradi… - Phytomedicine, 2023 - Elsevier
Abstract Background Neurodegenerative diseases (NDDs) are characterized by progressive
neuronal dysfunctionality which results in disability and human life-threatening events. In …

PCSK9, a novel immune and ferroptosis related gene in abdominal aortic aneurysm neck

J Zhuang, H Zhu, Z Cheng, X Hu, X Yu, J Li, H Liu… - Scientific Reports, 2023 - nature.com
The gene expression profile of abdominal aortic aneurysm (AAA) neck is not fully
understood. The etiology of AAA is considered to be related to atherosclerosis and the …

High mobility group box 1: biological functions and relevance in oxidative stress related chronic diseases

S Taverna, A Tonacci, M Ferraro, G Cammarata… - Cells, 2022 - mdpi.com
In the early 1970s, a group of non-histone nuclear proteins with high electrophoretic mobility
was discovered and named high-mobility group (HMG) proteins. High-mobility group box 1 …

Trends in NLRP3 inflammasome research in ischemic stroke from 2011 to 2022: A bibliometric analysis

H Zhu, Y Zhang, S Feng, Y Li, Y Ye… - CNS Neuroscience …, 2023 - Wiley Online Library
Background Ischemic stroke is a leading cause of permanent disability and death globally.
The nucleotide‐biding oligomaerization domain (NOD)‐like receptor family pyrin domain …

[HTML][HTML] Role of NLRP3 inflammasome in rheumatoid arthritis

H Yin, N Liu, KR Sigdel, L Duan - Frontiers in Immunology, 2022 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by multi-articular,
symmetrical and invasive arthritis resulting from immune system abnormalities involving T …

Neutrophil extracellular traps: a novel target for the treatment of stroke

Z Zhao, Z Pan, S Zhang, G Ma, W Zhang, J Song… - Pharmacology & …, 2023 - Elsevier
Stroke is a threatening cerebrovascular disease caused by thrombus with high morbidity
and mortality rates. Neutrophils are the first to be recruited in the brain after stroke, which …