It is generally accepted that chronic opioid use is associated with structural and functional
changes in the human brain that lead to an enhancement of impulsive behavior for …

Purpose Recovery following elective knee arthroscopy can be compromised by prolonged
postoperative opioid utilization, yet an effective and validated risk calculator for this outcome …

Nicotine causes psychological dependence through its interactions with nicotinic
acetylcholine receptors in the brain. We previously demonstrated that fatty acid-binding …

We previously demonstrated that fatty acid-binding protein 3 null (FABP3−/−) mice exhibit
resistance to nicotine-induced conditioned place preference (CPP). Here, we confirm that …

Relapse is a major challenge in the treatment of drug addiction, and exercise has been
shown to decrease relapse to drug seeking in animal models. However, the neural circuitry …

Oxycodone is one of the most commonly used analgesics in the clinic. However, longterm
use can contribute to drug dependence. Accumulating evidence of changes in DNA …

Background Methamphetamine (METH) is a highly addictive, psychoactive drug which can
harm individual health and lead to great social problems. Various approaches have been …

Background Internet addiction has been particularly prevalent among adolescents in recent
years. This type of addiction, similar to drug addiction, causes dependence and disturbance …

Background Opioid crisis has become a global concern, but whether physical activity (PA)
can effectively reduce prescription opioid use remains unclear. The study aimed to examine …

Addiction is a serious public health problem, and the current pharmacotherapy is unable to
prevent drug use reinstatement. Studies have focused on physical exercise as a promising …