[HTML][HTML] Pathogenesis of human cytomegalovirus in the immunocompromised host

P Griffiths, M Reeves - Nature Reviews Microbiology, 2021 - nature.com
Human cytomegalovirus (HCMV) is a herpesvirus that infects~ 60% of adults in developed
countries and more than 90% in developing countries. Usually, it is controlled by a vigorous …

Virological and immunological outcomes of coinfections

N Kumar, S Sharma, S Barua, BN Tripathi… - Clinical microbiology …, 2018 - Am Soc Microbiol
Coinfections involving viruses are being recognized to influence the disease pattern that
occurs relative to that with single infection. Classically, we usually think of a clinical …

[HTML][HTML] The efficacy and safety of 200 days valganciclovir cytomegalovirus prophylaxis in high‐risk kidney transplant recipients

A Humar, Y Lebranchu, F Vincenti, EA Blumberg… - American Journal of …, 2010 - Elsevier
Late‐onset cytomegalovirus (CMV) disease is a significant problem with a standard 3‐month
prophylaxis regimen. This multicentre, double‐blind, randomized controlled trial compared …

Overview of human cytomegalovirus pathogenesis

HL Fulkerson, MT Nogalski, D Collins-McMillen… - … : Methods and Protocols, 2021 - Springer
Human cytomegalovirus (HCMV) is a betaherpesvirus with a global seroprevalence of 60–
90%. HCMV is the leading cause of congenital infections and poses a great health risk to …

Role of cell culture for virus detection in the age of technology

DS Leland, CC Ginocchio - Clinical microbiology reviews, 2007 - Am Soc Microbiol
Viral disease diagnosis has traditionally relied on the isolation of viral pathogens in cell
cultures. Although this approach is often slow and requires considerable technical expertise …

[HTML][HTML] Cytomegalovirus: pathogen, paradigm, and puzzle

M Boeckh, AP Geballe - The Journal of clinical investigation, 2011 - Am Soc Clin Investig
Human cytomegalovirus (CMV), one of the eight herpesviruses that commonly infect
humans, is best known for its propensity to cause disease in immunocompromised patients …

Effect of preemptive therapy vs antiviral prophylaxis on cytomegalovirus disease in seronegative liver transplant recipients with seropositive donors: a randomized …

N Singh, DJ Winston, RR Razonable, GM Lyon… - Jama, 2020 - jamanetwork.com
Importance Despite the use of a cytomegalovirus (CMV) prevention strategy of antiviral
prophylaxis for high-risk CMV-seronegative liver transplant recipients with seropositive …

[HTML][HTML] Cytomegalovirus in solid organ transplant recipients

A Humar, D Snydman - American Journal of Transplantation, 2009 - amjtransplant.org
CMV infection is a major cause of morbidity in patients receiving solid organ transplants.
CMV is widely distributed in the general population with seroprevalence ranging from 30 to …

The immune response to human CMV

C La Rosa, DJ Diamond - Future virology, 2012 - Taylor & Francis
This review will summarize and interpret recent literature regarding the human CMV immune
response, which is among the strongest measured and is the focus of attention for numerous …

Extended valganciclovir prophylaxis in D+/R− kidney transplant recipients is associated with long-term reduction in cytomegalovirus disease: two-year results of the …

A Humar, AP Limaye, EA Blumberg, IA Hauser… - …, 2010 - journals.lww.com
Background. Whether the early reduction in cytomegalovirus (CMV) disease seen at 1 year
with prolongation of antiviral prophylaxis (up to 200 days) persists in the long term is …