Molecular mechanisms of action of genistein in cancer: Recent advances

HS Tuli, MJ Tuorkey, F Thakral, K Sak… - Frontiers in …, 2019 - frontiersin.org
Background: Genistein is one among the several other known isoflavones that is found in
different soybeans and soy products. The chemical name of genistein is 4′, 5, 7 …

[HTML][HTML] The anticancer mechanism of action of selected polyphenols in triple-negative breast cancer (TNBC)

R Farghadani, R Naidu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Breast cancer is a leadingcause of cancer-related deaths in women globally, with triple-
negative breast cancer (TNBC) being an aggressive subtype that lacks targeted therapies …

Genistein: a potent anti-breast cancer agent

SS Bhat, SK Prasad, C Shivamallu, KS Prasad… - Current Issues in …, 2021 - mdpi.com
Genistein is an isoflavonoid present in high quantities in soybeans. Possessing a wide
range of bioactives, it is being studied extensively for its tumoricidal effects. Investigations …

Recent updates on anticancer mechanisms of polyphenols

E Sharma, DC Attri, P Sati, P Dhyani… - Frontiers in Cell and …, 2022 - frontiersin.org
In today's scenario, when cancer cases are increasing rapidly, anticancer herbal
compounds become imperative. Studies on the molecular mechanisms of action of …

Anticancer or carcinogenic? The role of estrogen receptor β in breast cancer progression

K Shen, H Yu, B Xie, Q Meng, C Dong, K Shen… - Pharmacology & …, 2023 - Elsevier
Estrogen receptor β (ERβ) is closely related to breast cancer (BC) progression. Traditional
concepts regard ERβ as a tumor suppressor. As studies show the carcinogenic effect of …

Dual role of endoplasmic reticulum stress-mediated unfolded protein response signaling pathway in carcinogenesis

N Siwecka, W Rozpędek, D Pytel… - International journal of …, 2019 - mdpi.com
Cancer constitutes a grave problem nowadays in view of the fact that it has become one of
the main causes of death worldwide. Poor clinical prognosis is presumably due to cancer …

Therapeutic potentials of genistein: New insights and perspectives

S Rasheed, K Rehman, M Shahid… - Journal of Food …, 2022 - Wiley Online Library
Genistein, a polyphenolic isoflavone compound found abundantly in soy or soy‐based
products, is widely consumed in the Asian population. Genistein has poor bioavailability, to …

Targeting the crosstalk between canonical Wnt/β-catenin and inflammatory signaling cascades: A novel strategy for cancer prevention and therapy

D Tewari, S Bawari, S Sharma, LK DeLiberto… - Pharmacology & …, 2021 - Elsevier
Emerging scientific evidence indicates that inflammation is a critical component of tumor
promotion and progression. Most cancers originate from sites of chronic irritation, infections …

Anticancer potential of flavonoids: an overview with an emphasis on tangeretin

FCF de Luna, WAS Ferreira, SMM Casseb… - Pharmaceuticals, 2023 - mdpi.com
Natural compounds with pharmacological activity, flavonoids have been the subject of an
exponential increase in studies in the field of scientific research focused on therapeutic …

Engagement of phytoestrogens in breast cancer suppression: Structural classification and mechanistic approach

AK Tanwar, N Dhiman, A Kumar, V Jaitak - European Journal of Medicinal …, 2021 - Elsevier
Cancer is the world's devastating disease, and breast cancer is the most common reason for
the death of women worldwide. Many synthetic drugs and medications are provided with …