Pancreatic β cells secrete insulin in response to glucose, a process that is regulated at
multiple levels, including a network of input signals from other organ systems. Impaired islet …

Interleukin-1β is one of the most potent inducers of beta cell inflammation in the lead up to
type 1 diabetes. We have previously reported that IL1β-stimulated pancreatic islets from …

Diabetes mellitus-accelerated atherosclerosis (DMAS) is one of the vascular complications
of diabetes. Brain-derived neurotrophic factor (BDNF) plays a critical role in diabetes …

Hydroxyeicosatetraenoic acids (HETEs) are metabolites of arachidonate acid (AA) oxidized
by lipoxygenases or cytochrome P450 enzymes (CYP450). Since lipoxygenases and …

Type 2 diabetes mellitus (T2DM) is one of most common metabolic diseases and continues
to be a leading cause of death worldwide. Although great efforts have been made to …

Abstract Background The T helper 17 (Th17)/T regulatory (Treg) cell imbalance is involved
in the course of obesity and type 2 diabetes mellitus (T2DM). In the current study, the exact …

Macrophages are the most abundant immune cells of the tumor microenvironment (TME)
and have multiple important functions in cancer. During tumor growth, both tissue-resident …

Asprosin, encoded by penultimate two exons (exon 65 and exon 66) of the gene Fibrillin 1
(FBN1), has been recently discovered to be a novel hormone secreted by white adipose …

Neuroinflammation is documented to alter brain function as a consequence of metabolic
changes linked with a high‐fat diet (HFD). The primary target of this study is to see how …

Olfactory receptors (ORs) are widely expressed in extra-nasal tissues, where they participate
in the regulation of divergent physiological processes. An increasing body of evidence over …