CNS tumors remain among the deadliest forms of cancer, resisting conventional and new
treatment approaches, with mortality rates staying practically unchanged over the past 30 …

Glucose is the principle energy source for the mammalian brain. Delivery of glucose from the
blood to the brain requires transport across the endothelial cells of the blood‐brain barrier …

While transport processes for amino acids and glucose have long been known to be
expressed in the luminal and abluminal membranes of the endothelium comprising the …

Tolerance to cerebral ischemia is achieved by preconditioning sublethal stresses, such as
ischemia or hypoxia, paradigms in which the decrease of O2 availability may constitute an …

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that regulates adaptive responses
to the lack of oxygen in mammalian cells. HIF-1 consists of two proteins, HIF-1α and HIF-1β …

In conclusion, our immature rat model has gained wide acceptance as the animal model of
choice to study basic physiologic, biochemical, and molecular mechanisms of perinatal …

The effects of exogenous vascular endothelial growth factor (VEGF) on angiogenesis, blood–
brain barrier permeability and astroglial proliferation in the adult rat CNS in situ were …

An amazingly wide range of complex behavior emerges from the cerebral cortex. Much of
the information processing that leads to these behaviors is performed in neocortical circuits …

Despite the recognition that degenerative cartilage disorders like osteoarthritis (OA) and
osteochondritis dissecans (OCD) may have nutritional abnormalities at the root of their …

The effect of chronic hypobaric hypoxia (28 days, 455 Torr) on the organization of brain
vessels was studied in Balb/c mice. In comparison to age-matched controls kept at sea level …