Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1
Pancreatic ductal adenocarcinoma (PDA) is a lethal, therapy-resistant cancer that thrives in
a highly desmoplastic, nutrient-deprived microenvironment. Several studies investigated the …
a highly desmoplastic, nutrient-deprived microenvironment. Several studies investigated the …
[HTML][HTML] ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) cells reprogram their transcriptional and metabolic
programs to survive the nutrient-poor tumor microenvironment. Through in vivo CRISPR …
programs to survive the nutrient-poor tumor microenvironment. Through in vivo CRISPR …
[HTML][HTML] Macropinocytosis: mechanism and targeted therapy in cancers
F Xiao, J Li, K Huang, X Li, Y Xiong, M Wu… - American journal of …, 2021 - ncbi.nlm.nih.gov
Macropinocytosis is a form of endocytosis which provides an effective way for non-selective
uptakes of extracellular proteins, liquids, and particles. The endocytic process is initiated by …
uptakes of extracellular proteins, liquids, and particles. The endocytic process is initiated by …
Comprehensive high-throughput image analysis for therapeutic efficacy of architecturally complex heterotypic organoids
Abstract Bioengineered three-dimensional (3D) tumor models that incorporate heterotypic
cellular communication are gaining interest as they can recapitulate key features regarding …
cellular communication are gaining interest as they can recapitulate key features regarding …
Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells
Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with limited
treatment options. Pyruvate kinase, especially the M2 isoform (PKM2), is highly expressed in …
treatment options. Pyruvate kinase, especially the M2 isoform (PKM2), is highly expressed in …
GPx1 is involved in the induction of protective autophagy in pancreatic cancer cells in response to glucose deprivation
Q Meng, J Xu, C Liang, J Liu, J Hua, Y Zhang… - Cell Death & …, 2018 - nature.com
Given the dense stroma and poor vascularization, access to nutrients is limited in the
microenvironment of pancreatic ductal adenocarcinoma (PDA). PDA cells can efficiently …
microenvironment of pancreatic ductal adenocarcinoma (PDA). PDA cells can efficiently …
Targeting KRAS in pancreatic cancer: Emerging therapeutic strategies
KRAS, a predominant member of the RAS family, is the most frequently mutated oncogene
in human pancreatic cancer (∼ 95% of cases). Mutations in KRAS lead to its constitutive …
in human pancreatic cancer (∼ 95% of cases). Mutations in KRAS lead to its constitutive …
Biomimetic Gold Nanorods modified with erythrocyte membranes for imaging-guided Photothermal/Gene synergistic therapy
K Guo, S Ren, H Zhang, Y Cao, Y Zhao… - … applied materials & …, 2023 - ACS Publications
Pancreatic cancer (PC) is one of the most malignant cancers that develops rapidly and
carries a poor prognosis. Synergistic cancer therapy strategy could enhance the clinical …
carries a poor prognosis. Synergistic cancer therapy strategy could enhance the clinical …
Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer
Objective Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with limited
therapeutic options. However, metabolic adaptation to the harsh PDAC environment can …
therapeutic options. However, metabolic adaptation to the harsh PDAC environment can …
Glycolysis and tumor progression promoted by the m6A writer VIRMA via m6A-dependent upregulation of STRA6 in pancreatic ductal adenocarcinoma
K Yang, Z Zhong, J Zou, JY Liao, S Chen, S Zhou… - Cancer Letters, 2024 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal
malignancies, highlighting the urgent need to elucidate the underlying oncogenic …
malignancies, highlighting the urgent need to elucidate the underlying oncogenic …