Animal models of atrial fibrillation

D Schüttler, A Bapat, S Kääb, K Lee, P Tomsits… - Circulation …, 2020 - Am Heart Assoc
Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in humans and
is a significant source of morbidity and mortality. Despite its prevalence, our mechanistic …

Pathophysiological mechanisms of atrial fibrillation: a translational appraisal

U Schotten, S Verheule, P Kirchhof… - Physiological …, 2011 - journals.physiology.org
Atrial fibrillation (AF) is an arrhythmia that can occur as the result of numerous different
pathophysiological processes in the atria. Some aspects of the morphological and …

Driver domains in persistent atrial fibrillation

M Haissaguerre, M Hocini, A Denis, AJ Shah… - Circulation, 2014 - Am Heart Assoc
Background—Specific noninvasive signal processing was applied to identify drivers in
distinct categories of persistent atrial fibrillation (AF). Methods and Results—In 103 …

Comprehensive risk reduction in patients with atrial fibrillation: emerging diagnostic and therapeutic options—a report from the 3rd Atrial Fibrillation Competence …

P Kirchhof, GYH Lip, IC Van Gelder, J Bax, E Hylek… - Europace, 2012 - academic.oup.com
While management of atrial fibrillation (AF) patients is improved by guideline-conform
application of anticoagulant therapy, rate control, rhythm control, and therapy of …

Electrophysiological consequences of cardiac fibrosis

S Verheule, U Schotten - Cells, 2021 - mdpi.com
For both the atria and ventricles, fibrosis is generally recognized as one of the key
determinants of conduction disturbances. By definition, fibrosis refers to an increased …

Cardiac electrophysiology in mice: a matter of size

S Kaese, S Verheule - Frontiers in physiology, 2012 - frontiersin.org
Over the last decade, mouse models have become a popular instrument for studying cardiac
arrhythmias. This review assesses in which respects a mouse heart is a miniature human …

Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation

HMH Spronk, AM De Jong, S Verheule… - European heart …, 2017 - academic.oup.com
Aims Atrial fibrillation (AF) produces a hypercoagulable state. Stimulation of protease-
activated receptors by coagulation factors provokes pro-fibrotic, pro-hypertrophic, and pro …

A roadmap to improve the quality of atrial fibrillation management: proceedings from the fifth Atrial Fibrillation Network/European Heart Rhythm Association consensus …

P Kirchhof, G Breithardt, J Bax, G Benninger… - EP …, 2016 - academic.oup.com
At least 30 million people worldwide carry a diagnosis of atrial fibrillation (AF), and many
more suffer from undiagnosed, subclinical, or 'silent'AF. Atrial fibrillation-related …

Personalized management of atrial fibrillation: Proceedings from the fourth Atrial Fibrillation competence NETwork/European Heart Rhythm Association consensus …

P Kirchhof, G Breithardt, E Aliot, S Al Khatib… - Europace, 2013 - academic.oup.com
The management of atrial fibrillation (AF) has seen marked changes in past years, with the
introduction of new oral anticoagulants, new antiarrhythmic drugs, and the emergence of …

Transmural conduction is the predominant mechanism of breakthrough during atrial fibrillation: evidence from simultaneous endo-epicardial high-density activation …

J Eckstein, S Zeemering, D Linz, B Maesen… - Circulation …, 2013 - Am Heart Assoc
Background—Endo-epicardial dissociation (EED) of electric activations resulting in
transmural conduction of fibrillation waves (breakthroughs) has been postulated to …