Introduction Knowledge of the genetic mechanisms driving hereditary breast and ovarian
cancer (HBOC) has recently expanded due to advances in gene sequencing technologies …

Introduction Multifocal lung adenocarcinoma (MFLA) is becoming increasingly recognized
as a distinct subset of lung cancer, with unique biology, disease course, and treatment …

Simple Summary Familial cancer can be defined through the occurrence of the same cancer
in two or more family members. Hereditary cancer is a narrower definition of high-risk …

Background: Germline genetic testing (GT) for BRCA1/2 is instrumental in identifying
patients with breast and ovarian cancers who are eligible for PARP inhibitors (PARPi). Little …

Identifying causative genes via genetic testing is useful for screening, preventing and
treating cancer. Several hereditary syndromes occur in patients with renal cell carcinoma …

Large amounts of germline sequencing data have recently become available and we sought
to compare these results with population-based family history data. Family studies are able …

Expanded implementation of genetic sequencing has precipitously increased the discovery
of germline and somatic variants. The direct benefit of identifying variants in actionable …

One of the main factors influencing the clinical utility of genetic tests for cancer
predisposition is the ability to provide actionable classifications (ie pathogenic or benign) …

Introduction Rapid advancements in Next Generation Sequencing (NGS) and bioinformatics
tools have allowed physicians to obtain genetic testing results in a more rapid, cost-effective …

Multi‐cancer gene panels for hereditary cancer syndromes (hereditary cancer panels,
HCPs) are widely available, and some laboratories have programs that limit patients' out‐of …