Migraine, a primary headache disorder involving a dysfunctional trigeminal vascular system,
remains a major debilitating neurological condition impacting many patients' quality of life …

Migraine is one of the leading causes of disability worldwide, affecting work and social life. It
has been estimated that sales of migraine medicines will reach 12.9 billion USD in 2027. To …

Aims Chronic migraine (CM) is a common neurological disorder with complex pathogenesis.
Evidence suggests that pituitary adenylate cyclase-activating peptide (PACAP) induces …

The glymphatic system is important for waste removal in the central nervous system. It
removes soluble proteins and metabolic waste under the action of aquaporin-4 (AQP4) at …

Background Migraine headache attacks and accompanying sensory augmentation can be
induced by several agents including levcromakalim (LVC), that is also capable of provoking …

The individual and global burden of migraine is of such significance that there are
accelerated efforts to develop new therapies. New migraine therapeutics are needed to …

Objectives This study was designed to investigate the pharmacological activity and
therapeutic mechanism of Mahuang Xixin Fuzi decoction (MXFD) on migraine. Methods …

Migraine is a severely disabling primary neurological disorder. Although some studies have
confirmed that nitrogen dioxide (NO 2) pollution increases the risk of migraine, and our …

Background Post-traumatic headache is very common after a mild traumatic brain injury.
Post-traumatic headache may persist for months to years after an injury in a substantial …

Hyperalgesia resulting from sleep deprivation (SD) poses a significant a global public health
challenge with limited treatment options. The nucleus accumbens (NAc) plays a crucial role …