Although priming with replicating adenovirus type 5 host range mutant (Ad5hr)-human
immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) recombinants, followed …

Multiple myeloma (MM) is a rarely curable malignancy of plasma cells. MM expresses B cell
maturation antigen (BCMA). We developed a fully human anti-BCMA chimeric antigen …

Abstract Background Dendritic cells (DCs) can take up an array of different antigens,
including microorganisms which they can process and present more effectively than any …

The detection of antigen specific lymphocyte responses plays a vital role in the diagnosis of
various diseases. Beryllium-specific [3 H] thymidine lymphocyte proliferation test (LPT) is …

Therapy with interferon‐β (IFN‐β) has well‐established clinical effects in multiple sclerosis
(MS), albeit the immunomodulatory mechanisms are not fully understood. We assessed the …

Although hydroxychloroquine (HCQ) has long been used to treat autoimmune diseases, its
mechanism of action remains poorly understood. In CD4 T-cells, we found that a clinically …

Early therapy for hepatitis C virus (HCV) is associated with a high rate of viral clearance, but
the long-term effects on immune responses remain controversial. The role of antibodies …

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the CNS. The
numbers of autoimmune T cells and Abs specific for proteins of CNS myelin are increased in …

Type 1 diabetes is an autoimmune disease caused by T cell-mediated destruction of
pancreatic insulin-producing beta cells. The epitopes recognised by pathogenic T cells in …

The antiepileptic drug valproic acid (VPA) has been shown to influence the neural
differentiation and neurite outgrowth of neural stem cells. Sympathoadrenal progenitor cells …