Atopic dermatitis: an expanding therapeutic pipeline for a complex disease
T Bieber - Nature reviews Drug discovery, 2022 - nature.com
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …
Gut–skin axis: current knowledge of the interrelationship between microbial dysbiosis and skin conditions
B De Pessemier, L Grine, M Debaere, A Maes… - Microorganisms, 2021 - mdpi.com
The microbiome plays an important role in a wide variety of skin disorders. Not only is the
skin microbiome altered, but also surprisingly many skin diseases are accompanied by an …
skin microbiome altered, but also surprisingly many skin diseases are accompanied by an …
Atopic dermatitis endotypes and implications for targeted therapeutics
T Czarnowicki, H He, JG Krueger… - Journal of Allergy and …, 2019 - Elsevier
Recent research advancements indicate that atopic dermatitis (AD) is a complex disease
characterized by different subtypes/phenotypes based on age, disease chronicity, ethnicity …
characterized by different subtypes/phenotypes based on age, disease chronicity, ethnicity …
Atopic dermatitis: diagnosis and treatment
W Frazier, N Bhardwaj - American family physician, 2020 - aafp.org
Atopic dermatitis (atopic eczema) is a chronic relapsing and remitting inflammatory skin
disease affecting one in 10 people in their lifetime. Atopic dermatitis is caused by a complex …
disease affecting one in 10 people in their lifetime. Atopic dermatitis is caused by a complex …
Innovation in the treatment of atopic dermatitis: emerging topical and oral Janus kinase inhibitors
C Nakashima, S Yanagihara, A Otsuka - Allergology International, 2022 - jstage.jst.go.jp
abstract Atopic dermatitis (AD) is characterized by chronic, eczematous, severe pruritic skin
lesions. The knowledge on the pathogenesis of AD is driving the development of new drugs …
lesions. The knowledge on the pathogenesis of AD is driving the development of new drugs …
The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis
T Dainichi, A Kitoh, A Otsuka, S Nakajima… - Nature …, 2018 - nature.com
The skin provides both a physical barrier and an immunologic barrier to external threats. The
protective machinery of the skin has evolved to provide situation-specific responses to …
protective machinery of the skin has evolved to provide situation-specific responses to …
Interleukin‐31: The “itchy” cytokine in inflammation and therapy
The cytokine interleukin‐31 has been implicated in the pathophysiology of multiple atopic
disorders such as atopic dermatitis (AD), allergic rhinitis, and airway hyper‐reactivity. In AD …
disorders such as atopic dermatitis (AD), allergic rhinitis, and airway hyper‐reactivity. In AD …
[HTML][HTML] Neuroimmune communication regulating pruritus in atopic dermatitis
Atopic dermatitis (AD) is a common, chronic-relapsing inflammatory skin disease with
significant disease burden. Genetic and environmental trigger factors contribute to AD …
significant disease burden. Genetic and environmental trigger factors contribute to AD …
[HTML][HTML] Delgocitinib ointment, a topical Janus kinase inhibitor, in adult patients with moderate to severe atopic dermatitis: A phase 3, randomized, double-blind …
H Nakagawa, O Nemoto, A Igarashi, H Saeki… - Journal of the American …, 2020 - Elsevier
Background Previous studies showed the potential effectiveness of delgocitinib ointment, a
novel topical Janus kinase inhibitor, in atopic dermatitis (AD). Objective This study aimed to …
novel topical Janus kinase inhibitor, in atopic dermatitis (AD). Objective This study aimed to …
Peripheral itch sensitization in atopic dermatitis
M Tominaga, K Takamori - Allergology International, 2022 - jstage.jst.go.jp
abstract Atopic dermatitis is a skin disorder caused by skin dryness and barrier dysfunction,
resulting in skin inflammation and chronic itch (or pruritus). The pathogenesis of atopic …
resulting in skin inflammation and chronic itch (or pruritus). The pathogenesis of atopic …