Atopic dermatitis: an expanding therapeutic pipeline for a complex disease

T Bieber - Nature reviews Drug discovery, 2022 - nature.com
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …

Gut–skin axis: current knowledge of the interrelationship between microbial dysbiosis and skin conditions

B De Pessemier, L Grine, M Debaere, A Maes… - Microorganisms, 2021 - mdpi.com
The microbiome plays an important role in a wide variety of skin disorders. Not only is the
skin microbiome altered, but also surprisingly many skin diseases are accompanied by an …

Atopic dermatitis endotypes and implications for targeted therapeutics

T Czarnowicki, H He, JG Krueger… - Journal of Allergy and …, 2019 - Elsevier
Recent research advancements indicate that atopic dermatitis (AD) is a complex disease
characterized by different subtypes/phenotypes based on age, disease chronicity, ethnicity …

Atopic dermatitis: diagnosis and treatment

W Frazier, N Bhardwaj - American family physician, 2020 - aafp.org
Atopic dermatitis (atopic eczema) is a chronic relapsing and remitting inflammatory skin
disease affecting one in 10 people in their lifetime. Atopic dermatitis is caused by a complex …

Innovation in the treatment of atopic dermatitis: emerging topical and oral Janus kinase inhibitors

C Nakashima, S Yanagihara, A Otsuka - Allergology International, 2022 - jstage.jst.go.jp
abstract Atopic dermatitis (AD) is characterized by chronic, eczematous, severe pruritic skin
lesions. The knowledge on the pathogenesis of AD is driving the development of new drugs …

The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis

T Dainichi, A Kitoh, A Otsuka, S Nakajima… - Nature …, 2018 - nature.com
The skin provides both a physical barrier and an immunologic barrier to external threats. The
protective machinery of the skin has evolved to provide situation-specific responses to …

Interleukin‐31: The “itchy” cytokine in inflammation and therapy

A Datsi, M Steinhoff, F Ahmad, M Alam, J Buddenkotte - Allergy, 2021 - Wiley Online Library
The cytokine interleukin‐31 has been implicated in the pathophysiology of multiple atopic
disorders such as atopic dermatitis (AD), allergic rhinitis, and airway hyper‐reactivity. In AD …

[HTML][HTML] Neuroimmune communication regulating pruritus in atopic dermatitis

M Steinhoff, F Ahmad, A Pandey, A Datsi… - Journal of Allergy and …, 2022 - Elsevier
Atopic dermatitis (AD) is a common, chronic-relapsing inflammatory skin disease with
significant disease burden. Genetic and environmental trigger factors contribute to AD …

[HTML][HTML] Delgocitinib ointment, a topical Janus kinase inhibitor, in adult patients with moderate to severe atopic dermatitis: A phase 3, randomized, double-blind …

H Nakagawa, O Nemoto, A Igarashi, H Saeki… - Journal of the American …, 2020 - Elsevier
Background Previous studies showed the potential effectiveness of delgocitinib ointment, a
novel topical Janus kinase inhibitor, in atopic dermatitis (AD). Objective This study aimed to …

Peripheral itch sensitization in atopic dermatitis

M Tominaga, K Takamori - Allergology International, 2022 - jstage.jst.go.jp
abstract Atopic dermatitis is a skin disorder caused by skin dryness and barrier dysfunction,
resulting in skin inflammation and chronic itch (or pruritus). The pathogenesis of atopic …