Recent update and drug target in molecular and pharmacological insights into autophagy modulation in cancer treatment and future progress
Recent evidence suggests that autophagy is a governed catabolic framework enabling the
recycling of nutrients from injured organelles and other cellular constituents via a lysosomal …
recycling of nutrients from injured organelles and other cellular constituents via a lysosomal …
Prostate cancer and microRNAs: New insights into apoptosis
J Gupta, WK Abdulsahib, AT Jalil, DS Kareem… - … -Research and Practice, 2023 - Elsevier
Prostate cancer (PCa) is known as one of the most prevalent malignancies globally and is
not yet curable owing to its progressive nature. It has been well documented that Genetic …
not yet curable owing to its progressive nature. It has been well documented that Genetic …
Downregulation of miR-99b-5p and upregulation of nuclear mTOR cooperatively promotes the tumor aggressiveness and drug resistance in African American prostate …
Mammalian target of rapamycin (mTOR) regulates various fundamental cellular events
including cell proliferation, protein synthesis, metabolism, apoptosis, and autophagy. Tumor …
including cell proliferation, protein synthesis, metabolism, apoptosis, and autophagy. Tumor …
Deregulated microRNAs involved in prostate cancer aggressiveness and treatment resistance mechanisms
Simple Summary Accumulating studies have highlighted the critical roles of microRNAs in
tumorigenesis and cancer treatment responses. Here, we systematically review the scientific …
tumorigenesis and cancer treatment responses. Here, we systematically review the scientific …
Biomarkers for early detection of cancer: molecular aspects
PS Tappia, B Ramjiawan - International journal of molecular sciences, 2023 - mdpi.com
According to the World Health Organization, cancer is a leading cause of death worldwide,
representing almost 10 million deaths in 2020. In other words, approximately one death out …
representing almost 10 million deaths in 2020. In other words, approximately one death out …
MicroRNA-483-5p inhibits hepatocellular carcinoma cell proliferation, cell steatosis, and fibrosis by targeting PPARα and TIMP2
S Niture, S Gadi, Q Qi, MA Gyamfi, RS Varghese… - Cancers, 2023 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is the fifth leading and highly aggressive
lethal liver cancer. The most common cause of HCC is liver cirrhosis because of multiple …
lethal liver cancer. The most common cause of HCC is liver cirrhosis because of multiple …
Tumor suppressive miR-99b-5p as an epigenomic regulator mediating mTOR/AR/SMARCD1 signaling axis in aggressive prostate cancer
Introduction African American (AA) men exhibited 2.3-fold higher PCa incidence and 1.7-fold
higher PCa mortality rates when compared to the European American (EA) men. Besides …
higher PCa mortality rates when compared to the European American (EA) men. Besides …
Deregulated miRNAs in enzalutamide resistant prostate cancer: A comprehensive review of key molecular alterations and clinical outcomes
I Tavares, M Morais, F Dias, R Medeiros… - Biochimica et Biophysica …, 2023 - Elsevier
Prostate cancer (PC) is the second most frequently diagnosed cancer and the fifth leading
cause of cancer-related deaths in male population worldwide. Since the growth and …
cause of cancer-related deaths in male population worldwide. Since the growth and …
[HTML][HTML] High miR-99b expression is associated with cell proliferation and worse patient outcomes in breast cancer
Although miR-99b is a known suppressive microRNA (miRNA) in several cancers, its role in
breast cancer has not been elucidated. In this study, we examined the clinical relevance of …
breast cancer has not been elucidated. In this study, we examined the clinical relevance of …
The emerging roles of miRNA-mediated autophagy in ovarian cancer
Y Ding, X Huang, T Ji, C Qi, X Gao, R Wei - Cell Death & Disease, 2024 - nature.com
Ovarian cancer is one of the common tumors of the female reproductive organs. It has a high
mortality rate, is highly heterogeneous, and early detection and primary prevention are very …
mortality rate, is highly heterogeneous, and early detection and primary prevention are very …