Advantages and limitations of animal schizophrenia models

M Białoń, A Wąsik - International Journal of Molecular Sciences, 2022 - mdpi.com
Mental illness modeling is still a major challenge for scientists. Animal models of
schizophrenia are essential to gain a better understanding of the disease etiopathology and …

Biological hypotheses, risk factors, and biomarkers of schizophrenia

Z Fišar - Progress in Neuro-Psychopharmacology and …, 2023 - Elsevier
Both the discovery of biomarkers of schizophrenia and the verification of biological
hypotheses of schizophrenia are an essential part of the process of understanding the …

Modeling psychotic disorders: Environment x environment interaction

K Murlanova, MV Pletnikov - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
Schizophrenia is a major psychotic disorder with multifactorial etiology that includes
interactions between genetic vulnerability and environmental risk factors. In addition …

[HTML][HTML] Prenatal infection and adolescent social adversity affect microglia, synaptic density, and behavior in male rats

CGJ Guerrin, K Prasad, DA Vazquez-Matias… - Neurobiology of …, 2023 - Elsevier
Maternal infection during pregnancy and childhood social trauma have been associated
with neurodevelopmental and affective disorders, such as schizophrenia, autism spectrum …

Immune activation during pregnancy exacerbates ASD-related alterations in Shank3-deficient mice

E Atanasova, AP Arévalo, I Graf, R Zhang, J Bockmann… - Molecular Autism, 2023 - Springer
Background Autism spectrum disorder (ASD) is mainly characterized by deficits in social
interaction and communication and repetitive behaviors. Known causes of ASD are …

[HTML][HTML] Nanosystems for brain targeting of antipsychotic drugs: An update on the most promising nanocarriers for increased bioavailability and therapeutic efficacy

MD Ferreira, J Duarte, F Veiga, AC Paiva-Santos… - Pharmaceutics, 2023 - mdpi.com
Orally administered antipsychotic drugs are the first-line treatment for psychotic disorders,
such as schizophrenia and bipolar disorder. Nevertheless, adverse drug reactions …

Canonical and non-canonical antipsychotics' dopamine-related mechanisms of present and next generation molecules: a systematic review on translational highlights …

A de Bartolomeis, M Ciccarelli, G De Simone… - International Journal of …, 2023 - mdpi.com
Schizophrenia is a severe psychiatric illness affecting almost 25 million people worldwide
and is conceptualized as a disorder of synaptic plasticity and brain connectivity …

Evaluating different models of maternal stress on stress-responsive systems in prepubertal mice

JA Sheng, RJ Handa, SA Tobet - Frontiers in Neuroscience, 2023 - frontiersin.org
Introduction Maternal adversity during pregnancy influences neurodevelopment in human
and model animal offspring. Adversity can result from stressors coming from many different …

Prenatal risk factors and postnatal cannabis exposure: assessing dual models of schizophrenia-like rodents

C Martín-Cuevas, VD Ramos-Herrero… - Neuroscience & …, 2023 - Elsevier
Schizophrenia (SCZ) is a multifactorial neurodevelopmental disorder caused by genetic and
environmental alterations, especially during prenatal stages. On the other hand, cannabis …

Sex‐specific susceptibility to psychotic‐like states provoked by prenatal THC exposure: Reversal by pregnenolone

R Frau, M Melis - Journal of Neuroendocrinology, 2023 - Wiley Online Library
Sociocultural attitudes towards cannabis legalization contribute to the common
misconception that it is a relatively safe drug and its use during pregnancy poses no risk to …