New directions in therapeutic angiogenesis and arteriogenesis in peripheral arterial disease
The prevalence of peripheral arterial disease (PAD) in the United States exceeds 10 million
people, and PAD is a significant cause of morbidity and mortality across the globe. PAD is …
people, and PAD is a significant cause of morbidity and mortality across the globe. PAD is …
[HTML][HTML] Advanced model systems and tools for basic and translational human immunology
There are fundamental differences between humans and the animals we typically use to
study the immune system. We have learned much from genetically manipulated and inbred …
study the immune system. We have learned much from genetically manipulated and inbred …
An appraisal of vascular endothelial growth factor (VEGF): The dynamic molecule of wound healing and its current clinical applications
Angiogenesis is a critical step of wound healing, and its failure leads to chronic wounds. The
idea of restoring blood flow to the damaged tissues by promoting neo-angiogenesis is …
idea of restoring blood flow to the damaged tissues by promoting neo-angiogenesis is …
[HTML][HTML] VEGF-A splice variants bind VEGFRs with differential affinities
SB Mamer, A Wittenkeller, PI Imoukhuede - Scientific reports, 2020 - nature.com
Vascular endothelial growth factor A (VEGF-A) and its binding to VEGFRs is an important
angiogenesis regulator, especially the earliest-known isoform, VEGF-A165a. Yet several …
angiogenesis regulator, especially the earliest-known isoform, VEGF-A165a. Yet several …
Targeting Anti-Angiogenic VEGF165b–VEGFR1 Signaling Promotes Nitric Oxide Independent Therapeutic Angiogenesis in Preclinical Peripheral Artery Disease …
Nitric oxide (NO) is the critical regulator of VEGFR2-induced angiogenesis. Neither VEGF-A
over-expression nor L-Arginine (NO-precursor) supplementation has been effective in …
over-expression nor L-Arginine (NO-precursor) supplementation has been effective in …
Anti-angiogenic isoform of vascular endothelial growth factor-A in cardiovascular and renal disease
R Kikuchi, M Stevens, K Harada, S Oltean… - Advances in clinical …, 2019 - Elsevier
Accumulating evidence suggests that pathologic interactions between the heart and the
kidney can contribute to the progressive dysfunction of both organs. Recently, there has …
kidney can contribute to the progressive dysfunction of both organs. Recently, there has …
Integrative meta-modeling identifies endocytic vesicles, late endosome and the nucleus as the cellular compartments primarily directing RTK signaling
JC Weddell, PI Imoukhuede - Integrative Biology, 2017 - academic.oup.com
Recently, intracellular receptor signaling has been identified as a key component mediating
cell responses for various receptor tyrosine kinases (RTKs). However, the extent each …
cell responses for various receptor tyrosine kinases (RTKs). However, the extent each …
Systems pharmacology of VEGF165b in peripheral artery disease
We built a whole‐body computational model to study the role of the poorly understood
vascular endothelial growth factor (VEGF) 165b splice isoform in peripheral artery disease …
vascular endothelial growth factor (VEGF) 165b splice isoform in peripheral artery disease …
Balance between angiogenic and anti-angiogenic isoforms of VEGF-A is associated with the complexity and severity of coronary artery disease
Y Shibata, R Kikuchi, H Ishii, S Suzuki, K Harada… - Clinica chimica acta, 2018 - Elsevier
Introduction Assessing the complexity of coronary artery disease (CAD) is clinically
important. Vascular endothelial growth factor A (VEGF-A) is a powerful and the most …
important. Vascular endothelial growth factor A (VEGF-A) is a powerful and the most …
Dynamic multiscale regulation of perfusion recovery in experimental peripheral arterial disease: a mechanistic computational model
In peripheral arterial disease (PAD), the degree of endogenous capacity to modulate
revascularization of limb muscle is central to the management of leg ischemia. To …
revascularization of limb muscle is central to the management of leg ischemia. To …