Antimicrobial peptides (AMPs) are potent, mostly cationic, and amphiphilic broad-spectrum
host defense antimicrobials that are produced by all organisms ranging from prokaryotes to …

This review covers some of the recent progress in the field of peptide antibiotics with a focus
on compounds with novel or established mode of action and with demonstrated efficacy in …

Pathways of bacterial energy metabolism, such as the proton motive force (PMF), have
largely remained unexplored as drug targets, owing to toxicity concerns. Here, we elaborate …

Today's human society, product of decades of progress in all fields of knowledge, would
have been unimaginable without the discovery of antibiotics and more generally of …

Bacteriocins are ribosomally synthesized antimicrobial peptides produced by Bacteria and
some Archaea. The assessment of the toxic potential of antimicrobial peptides is important in …

(Figure 1A). Cholesterol has been shown to protect human erythrocytes from attack by
magainin 2 (Matsuzaki et al., 1995b). Similar studies on model membranes have …

The rapid development of multidrug-resistant (MDR) bacteria due to the improper and
overuse of antibiotics and the ineffective performance of antibiotics against the difficult-to …

The investigation on antimicrobial mechanisms is a challenging and crucial issue in the
fields of food or clinical microbiology, as it constitutes a prerequisite to the development of …

Antimicrobial peptides (AMPs) attack bacterial membranes selectively, killing microbes at
concentrations that cause no toxicity to the host cells. This selectivity is not due to interaction …

Enteric defensins likely play a key role in the management of the human microbiome
throughout development. The functional and mechanistic diversity of defensins is much …