Bile acids as metabolic regulators and nutrient sensors

JYL Chiang, JM Ferrell - Annual review of nutrition, 2019 - annualreviews.org
Bile acids facilitate nutrient absorption and are endogenous ligands for nuclear receptors
that regulate lipid and energy metabolism. The brain–gut–liver axis plays an essential role in …

[HTML][HTML] The role of vitamin D and vitamin D binding protein in chronic liver diseases

TL Pop, C Sîrbe, G Benţa, A Mititelu… - International journal of …, 2022 - mdpi.com
Vitamin D (calciferol) is a fat-soluble vitamin that has a significant role in phospho-calcium
metabolism, maintaining normal calcium levels and bone health development. The most …

Prenatal exposure to perfluoroalkyl substances associated with increased susceptibility to liver injury in children

N Stratakis, DV Conti, R Jin, K Margetaki, D Valvi… - Hepatology, 2020 - journals.lww.com
The severe acute respiratory syndrome coronavirus 2 pandemic has drastically altered all
facets of clinical care and research. Clinical research in hepatology has had a rich tradition …

[HTML][HTML] Biliary Atresia–emerging diagnostic and therapy opportunities

U Lendahl, VCH Lui, PHY Chung, PKH Tam - EBioMedicine, 2021 - thelancet.com
Biliary Atresia is a devastating pediatric cholangiopathy affecting the bile ducts of the liver. In
this review, we describe recent progress in the understanding of liver development with a …

[HTML][HTML] Long noncoding RNA H19 contributes to cholangiocyte proliferation and cholestatic liver fibrosis in biliary atresia

Y Xiao, R Liu, X Li, EC Gurley, PB Hylemon, Y Lu… - Hepatology, 2019 - journals.lww.com
Idiosyncratic drug‐induced liver injury (DILI) is a rare, often difficult‐to‐predict adverse
reaction with complex pathomechanisms. However, it is now evident that certain forms of …

Diagnostic yield of newborn screening for biliary atresia using direct or conjugated bilirubin measurements

S Harpavat, JA Garcia-Prats, C Anaya, ML Brandt… - Jama, 2020 - jamanetwork.com
Importance Treating biliary atresia in newborns earlier can delay or prevent the need for
liver transplant; however, treatment typically occurs later because biliary atresia is difficult to …

Biliary organoids uncover delayed epithelial development and barrier function in biliary atresia

SP Amarachintha, R Mourya, H Ayabe, L Yang… - …, 2022 - Wiley Online Library
Abstract Background and Aims Biliary atresia is a severe inflammatory and fibrosing
cholangiopathy of neonates of unknown etiology. The onset of cholestasis at birth implies a …

Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases

L Fabris, R Fiorotto, C Spirli, M Cadamuro… - Nature Reviews …, 2019 - nature.com
Bile duct epithelial cells, also known as cholangiocytes, regulate the composition of bile and
its flow. Acquired, congenital and genetic dysfunctions in these cells give rise to a set of …

Cholestatic liver diseases of genetic etiology: Advances and controversies

SH Ibrahim, BM Kamath, KM Loomes, SJ Karpen - Hepatology, 2022 - journals.lww.com
With the application of modern investigative technologies, cholestatic liver diseases of
genetic etiology are increasingly identified as the root cause of previously designated …

Management of biliary atresia in France 1986 to 2015: long-term results

M Fanna, G Masson, C Capito, M Girard… - Journal of pediatric …, 2019 - journals.lww.com
Objectives: This study analyses the prognosis of biliary atresia (BA) in France since 1986,
when both Kasai operation (KOp) and liver transplantation (LT) became widely available …