[HTML][HTML] Senescence and senotherapies in biliary atresia and biliary cirrhosis

G Jannone, EB Riani, C de Magnée… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Background: Premature senescence occurs in adult hepatobiliary diseases and worsens the
prognosis through deleterious liver remodeling and hepatic dysfunction. Senescence might …

[HTML][HTML] Recent advances in understanding biliary atresia

A Wehrman, O Waisbourd-Zinman, RG Wells - F1000Research, 2019 - ncbi.nlm.nih.gov
Biliary atresia (BA) is a neonatal liver disease characterized by progressive obstruction and
fibrosis of the extrahepatic biliary tree as well as fibrosis and inflammation of the liver …

Clinical research in hepatology in the COVID‐19 pandemic and post‐pandemic era: challenges and the need for innovation

EC Verna, M Serper, J Chu, K Corey, OK Fix… - …, 2020 - Wiley Online Library
The severe acute respiratory syndrome coronavirus 2 pandemic has drastically altered all
facets of clinical care and research. Clinical research in hepatology has had a rich tradition …

The utility of shear wave elastography and serum biomarkers for diagnosing biliary atresia and predicting clinical outcomes

Y Liu, C Peng, K Wang, D Wu, J Yan, W Tu… - European journal of …, 2022 - Springer
To investigate the utility of liver stiffness measurement by shear wave elastography (SWE)
and several commonly used biomarkers in differentiating biliary atresia (BA) from other …

Effect and mechanism of vitamin D activation disorder on liver fibrosis in biliary atresia

S Sun, M Xu, P Zhuang, G Chen, K Dong, R Dong… - Scientific Reports, 2021 - nature.com
To investigate the mechanism of 25 hydroxyvitamin D (25 (OH) D) deficiency in children with
biliary atresia (BA) and its effect on liver fibrosis. The serum vitamin D and 25 (OH) D, and …

Predictive model containing gene signature and shear wave elastography to predict patient outcomes after Kasai surgery in biliary atresia

G Wang, H Chen, P Sun, W Zhou, H Jiang… - Hepatology …, 2023 - Wiley Online Library
Aims Infants with biliary atresia (BA) are treated with Kasai portoenterostomy (KPE) surgery,
but many BA patients need subsequent salvage liver transplants. The aim of this study is to …

Diagnostic accuracy of serum matrix metalloproteinase-7 as a biomarker of biliary atresia in a large North American cohort

S Pandurangi, R Mourya, S Nalluri, L Fei, S Dong… - Hepatology, 2024 - journals.lww.com
Conclusions: Serum MMP-7 has high discriminative properties to differentiate BA from other
forms of neonatal cholestasis. MMP-7 cutoff values vary according to assay technology …

Serum FGF19 predicts outcomes of Kasai portoenterostomy in biliary atresia

I Nyholm, M Hukkinen, M Pihlajoki, JR Davidson… - Hepatology, 2023 - journals.lww.com
Serum FGF19 predicts outcomes of Kasai portoenterostomy in b... : Hepatology Serum FGF19
predicts outcomes of Kasai portoenterostomy in biliary atresia : Hepatology AASLD Publications …

Plasticity between type 2 innate lymphoid cell subsets and amphiregulin expression regulates epithelial repair in biliary atresia

AE Russi, P Shivakumar, Z Luo, JA Bezerra - Hepatology, 2023 - journals.lww.com
Conclusions: These findings identify a key function of the IL-13/IL-4Rα/STAT6 pathway in
ILC2 plasticity and an alternate circuit driven by IL-2 to promote nILC2 stability and …

Opportunities and considerations for studying liver disease with microphysiological systems on a chip

AE Otumala, DJ Hellen, CA Luna, P Delgado… - Lab on a Chip, 2023 - pubs.rsc.org
Advances in microsystem engineering have enabled the development of highly controlled
models of the liver that better recapitulate the unique in vivo biological conditions. In just a …