Elastography for pediatric chronic liver disease: a review and expert opinion

G Ferraioli, RG Barr, JR Dillman - Journal of Ultrasound in …, 2021 - Wiley Online Library
In adults with chronic liver diseases, ultrasound and magnetic resonance shear wave
elastography (SWE) can replace liver biopsy in several clinical scenarios. Several …

A phase I/IIa trial of intravenous immunoglobulin following portoenterostomy in biliary atresia

CL Mack, C Spino, EM Alonso, JA Bezerra… - Journal of pediatric …, 2019 - journals.lww.com
Objectives: Biliary atresia (BA) is a progressive neonatal fibroinflammatory cholangiopathy.
We hypothesized that intravenous immunoglobulin (IVIg) would be safe, feasible …

Predicting native liver injury and survival in biliary atresia

M Hukkinen, M Pihlajoki, MP Pakarinen - Seminars in Pediatric Surgery, 2020 - Elsevier
Several patient and treatment related factors significantly modify outcomes of biliary atresia.
The extremely variable prognosis mandates intensive postoperative monitoring following …

Extrahepatic cholangiocyte obstruction is mediated by decreased glutathione, Wnt and Notch signaling pathways in a toxic model of biliary atresia

S Fried, D Gilboa, A Har-Zahav, PM Lavrut, Y Du… - Scientific reports, 2020 - nature.com
Biliary atresia is a neonatal liver disease with extrahepatic bile duct obstruction and
progressive liver fibrosis. The etiology and pathogenesis of the disease are unknown. We …

Periductal bile acid exposure causes cholangiocyte injury and fibrosis

M Dotan, S Fried, A Har-Zahav, R Shamir, RG Wells… - Plos one, 2022 - journals.plos.org
Introduction Bile duct integrity is essential for the maintenance of the structure and function
of the biliary tree. We previously showed that cholangiocyte injury in a toxic model of biliary …

Unique Cholangiocyte‐Targeted IgM Autoantibodies Correlate With Poor Outcome in Biliary Atresia

Y Luo, D Brigham, J Bednarek, R Torres, D Wang… - Hepatology, 2021 - journals.lww.com
Conclusions BA is associated with cholangiocyte‐predominant IgM autoantibodies in the
first year after Kasai portoenterostomy. Anti‐CHI3L1, anti‐DLL‐4, and anti‐SFTPD IgM …

Interpretable artificial intelligence-based app assists inexperienced radiologists in diagnosing biliary atresia from sonographic gallbladder images

W Zhou, Z Ye, G Huang, X Zhang, M Xu, B Liu… - BMC medicine, 2024 - Springer
Background A previously trained deep learning-based smartphone app provides an artificial
intelligence solution to help diagnose biliary atresia from sonographic gallbladder images …

Unsupervised clustering reveals distinct subtypes of biliary atresia based on immune cell types and gene expression

X Pang, J Cao, S Chen, Z Gao, G Liu, Y Chong… - Frontiers in …, 2021 - frontiersin.org
Background Biliary atresia (BA) is a severe cholangiopathy of early infancy that destroys
cholangiocytes, obstructs ductular pathways and if left untreated, culminates to liver …

Gut microbiome: a potential modifiable risk factor in biliary atresia

V Jain, EC Alexander, C Burford, A Verma… - Journal of Pediatric …, 2021 - journals.lww.com
Biliary atresia (BA) is a fibro-obliterative condition of the biliary tree, presenting in infancy.
The bilioenteric conduit formed at Kasai portoenterostomy (KPE), achieves restoration of bile …

Neurodevelopmental outcomes in preschool and school aged children with biliary atresia and their native liver

JE Squires, VL Ng, K Hawthorne, LL Henn… - Journal of pediatric …, 2020 - journals.lww.com
Neurodevelopmental Outcomes in Preschool and School Aged Chi... : Journal of Pediatric
Gastroenterology and Nutrition Neurodevelopmental Outcomes in Preschool and School …