The diagnostic performance of ultrasound elastography for biliary atresia: A meta-analysis

B Dong, Z Weng, G Lyu, X Yang, H Wang - Frontiers in Public Health, 2022 - frontiersin.org
Background Biliary atresia (BA) is a severe inflammatory obliterative cholangiopathy of
infancy that requires early diagnosis and prompt surgical intervention. In this study, we …

Insight into bile duct reaction to obstruction from a three-dimensional perspective using ex vivo phase-contrast CT

WJ Lv, XY Zhao, DD Hu, XH Xin, LL Qin, CH Hu - Radiology, 2021 - pubs.rsna.org
Background Biliary obstruction leads to an increase in biliary pressure within the biliary
system, which induces the morphologic adaptation of the biliary tree. Purpose To observe …

Current and emerging adjuvant therapies in biliary atresia

SC Fligor, TI Hirsch, ST Tsikis, A Adeola… - Frontiers in …, 2022 - frontiersin.org
Following Kasai hepatic portoenterostomy (HPE), most patients with biliary atresia will
eventually require liver transplantation due to progressive cirrhosis and liver failure …

Cytomegalovirus in biliary atresia is associated with increased pretransplant death, but not decreased native liver survival

S Kemme, JD Canniff, AG Feldman… - Hepatology …, 2023 - journals.lww.com
Background: Biliary atresia (BA) is likely caused by a common phenotypic response to
various triggers; one proposed trigger, cytomegalovirus (CMV), may lead to worse …

Reduced peroxisome proliferator-activated receptor-α and bile acid nuclear receptor NR1H4/FXR may affect the hepatic immune microenvironment of biliary atresia

Y Ma, L Lu, K Tan, Z Li, T Guo, Y Wu, W Wu… - Frontiers in …, 2022 - frontiersin.org
Background Biliary atresia (BA) is a childhood liver disease characterized by fibrous
obstruction and obstruction of the extrahepatic biliary system and is one of the most common …

Granulocyte-colony stimulating factor GCSF mobilizes hematopoietic stem cells in Kasai patients with biliary atresia in a phase 1 study and improves short term …

AX Holterman, HPA Nguyen, E Nadler, GH Vu… - Journal of Pediatric …, 2021 - Elsevier
Aims In RCT of adults with decompensated cirrhosis, GCSF mobilizes hematopoietic stem
cells HSC and improves short-term outcome. An FDA-IND for sequential Kasai-GCSF …

[HTML][HTML] Liver organoids: established tools for disease modeling and drug development

XC Sun, D Kong, J Zhao, KN Faber… - Hepatology …, 2023 - journals.lww.com
Abbreviations: α-SMA, alpha-smooth muscle; A1AT, alpha-1 antitrypsin; AALD, alcohol-
associated liver disease; AATD, alpha-1 antitrypsin deficiency; ACE2, angiotensin 1 …

[PDF][PDF] Noninvasive evaluation of liver fibrosis and portal hypertension after successful portoenterostomy for biliary atresia

M Hukkinen, J Lohi, P Heikkilä… - Hepatology …, 2019 - Wiley Online Library
We investigated noninvasive follow‐up markers for histologic liver fibrosis and portal
hypertension (PH) in patients with biliary atresia after successful portoenterostomy (PE) …

Pkd1l1-deficiency drives biliary atresia through ciliary dysfunction in biliary epithelial cells

YZ Lim, M Zhu, Y Wang, T Sharma, S Kelley… - Journal of …, 2024 - Elsevier
Background & Aims Syndromic biliary atresia is a cholangiopathy characterized by fibro-
obliterative changes in the extrahepatic bile duct (EHBD) and congenital malformations …

[PDF][PDF] Clinical consequences of cardiomyopathy in children with biliary atresia requiring liver transplantation

NM Gorgis, C Kennedy, F Lam, K Thompson… - …, 2019 - Wiley Online Library
Cirrhotic cardiomyopathy (CCM), a comorbidity of end‐stage cirrhotic liver disease, remains
uncharacterized in children, largely because of a lack of an established pediatric definition …