An apparent paradox exists between the evidence for spontaneous systemic T cell-mediated
anti-tumor immune responses in cancer patients, observed particularly in their bone marrow …

The rewiring of cellular metabolism is a defining characteristic of cancer, as tumor cells
adapt to acquire essential nutrients from a nutrient-poor environment to sustain their viability …

Many cancers begin with the formation of a small nest of transformed cells that can remain
dormant for years. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing …

Cancer-associated fibroblasts (CAFs) are critical for cancer occurrence and progression in
the tumor microenvironment (TME), due to their versatile roles in extracellular matrix …

Cancer survivors undergone treatment face an increased risk of developing atherosclerotic
cardiovascular disease (CVD), yet the underlying mechanisms remain elusive. Recent …

Cancer‐associated fibroblasts (CAFs) are a key component of the tumor microenvironment
and a critical factor in the progression of colorectal cancer (CRC). The aim of this study was …

Extracellular vesicles (EVs) are subcellular messengers that aid in the formation and spread
of cancer by enabling tumor-stroma communication. EVs develop from the very porous …

Simple Summary Gastrointestinal (GI) cancers are the leading cancer-related deaths
worldwide. Despite improved survival rates with current treatments, recurrence remains a …

Fibroblasts are crucial to normal and abnormal organ and tissue biology, yet we lack basic
insights into the fibroblasts that populate the bladder wall. Candidates may include bladder …

Background Chimeric antigen receptor (CAR) T-cells are a promising approach in cancer
immunotherapy, particularly for treating hematologic malignancies. Yet, their effectiveness is …