Drug development for ischemic stroke is challenging as evidenced by the paucity of
therapeutics that have advanced beyond a phase III trial. There are many reasons for this …

Intrinsic biological clocks drive the circadian rhythm, which coordinates the physiological
and pathophysiological processes in the body. Recently, a bidirectional relationship …

Time-of-day significantly influences the severity and incidence of stroke. Evidence has
emerged not only for circadian governance over stroke risk factors, but also for important …

The blood-brain barrier (BBB) is a critical interface separating the central nervous system
from the peripheral circulation, ensuring brain homeostasis and function. Recent research …

Ischemic stroke is a major public health problem worldwide. Although the circadian clock is
involved in the process of ischemic stroke, the exact mechanism of the circadian clock in …

In recent years, the association between microRNAs (miRNAs) and autophagy in cerebral
infarction (CI) has attracted increasingly more attention. The mammalian target of the …

The circadian system is widely involved in the various pathological outcomes affected by
time dimension changes. In the brain, the master circadian clock, also known as the …

Crosstalk between central nervous system (CNS) and systemic responses is important in
many pathological conditions, including stroke, neurodegeneration, schizophrenia, epilepsy …

Accumulating evidence suggests that astrocytes, the abundant cell type in the central
nervous system (CNS), play a critical role in maintaining the immune response after cerebral …

Background The hemoglobin to red cell distribution width ratio (HRR) has been
experimentally associated with the prognosis of acute ischemic stroke (AIS). However, its …