The concept of intrinsic versus extrinsic apoptosis

L Lossi - Biochemical Journal, 2022 - portlandpress.com
Regulated cell death is a vital and dynamic process in multicellular organisms that maintains
tissue homeostasis and eliminates potentially dangerous cells. Apoptosis, one of the better …

Targeting ferroptosis: pathological mechanism and treatment of ischemia‐reperfusion injury

X Li, N Ma, J Xu, Y Zhang, P Yang, X Su… - Oxidative Medicine …, 2021 - Wiley Online Library
Ischemia‐reperfusion (I/R) is a pathological process that occurs in many organs and
diseases. Reperfusion, recovery of blood flow, and reoxygenation often lead to reperfusion …

Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion

Q Tuo, Y Liu, Z Xiang, HF Yan, T Zou, Y Shu… - Signal transduction and …, 2022 - nature.com
Ischemic stroke represents a significant danger to human beings, especially the elderly.
Interventions are only available to remove the clot, and the mechanism of neuronal death …

Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis

J Luoqian, W Yang, X Ding, Q Tuo, Z Xiang… - Cellular & molecular …, 2022 - nature.com
While many drugs are effective at reducing the relapse frequency of multiple sclerosis (MS),
there is an unmet need for treatments that slow neurodegeneration resulting from secondary …

Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke

C Li, G Sun, B Chen, L Xu, Y Ye, J He, Z Bao… - Pharmacological …, 2021 - Elsevier
Ischemic stroke poses a significant health risk due to its high rate of disability and mortality.
To address this problem, several therapeutic approaches have been proposed, including …

Neuronal death mechanisms and therapeutic strategy in ischemic stroke

R Mao, N Zong, Y Hu, Y Chen, Y Xu - Neuroscience bulletin, 2022 - Springer
Ischemic stroke caused by intracranial vascular occlusion has become increasingly
prevalent with considerable mortality and disability, which gravely burdens the global …

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

Y Wang, J Hu, S Wu, JS Fleishman, Y Li, Y Xu… - … and Targeted Therapy, 2023 - nature.com
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

Iron, ferroptosis, and ischemic stroke

J Guo, Q Tuo, P Lei - Journal of Neurochemistry, 2023 - Wiley Online Library
Over 30 million people suffer from the consequences of ischemic stroke. The precise
molecular mechanism of neuronal damage during ischemic stroke remains unclear; …

Ferroptosis‐modulating small molecules for targeting drug‐resistant cancer: Challenges and opportunities in manipulating redox signaling

SC Koeberle, AP Kipp, H Stuppner… - Medicinal Research …, 2023 - Wiley Online Library
Ferroptosis is an iron‐dependent cell death program that is characterized by excessive lipid
peroxidation. Triggering ferroptosis has been proposed as a promising strategy to fight …

Knowledge mapping of necroptosis from 2012 to 2021: a bibliometric analysis

J Zhang, L Song, J Jia, W Tian, R Lai, Z Zhang… - Frontiers in …, 2022 - frontiersin.org
Background Necroptosis, a recently discovered programmed cell death, has been
pathologically linked to various diseases and is thus a promising target for treating diseases …