Inflammation is a protective response of the body potentially caused by microbial, viral, or
fungal infections, tissue damage, or even autoimmune reactions. The cardinal signs of …

The Janus kinases (JAKs) are key components of the JAK-STAT signaling pathway and are
involved in myriad physiological processes. Though they are the molecular targets of many …

Janus Kinase-1 (JAK1) plays key roles during neurodevelopment and following neuronal
injury, while activatory JAK1 mutations are linked to leukemia. In mice, Jak1 genetic deletion …

Deciphering the intricate dynamic events governing type I interferon (IFN) signaling is critical
to unravel key regulatory mechanisms in host antiviral defense. Here, we leverage TurboID …

Janus kinase 2 (JAK2) mediates type I/II cytokine receptor signaling, but JAK2 is also
activated by somatic mutations that cause hematological malignancies by mechanisms that …

Introduction Somatic mutations in myeloid growth factor pathway genes, such as JAK2, and
genes involved in epigenetic regulation, such as TET2, in hematopoietic stem cells (HSCs) …

Advances in genome sequencing and editing technologies have enriched our
understanding of the biochemical pathways that drive tumorigenesis. Translating this …

Homodimeric class 1 cytokine receptors include the erythropoietin (EPOR), thrombopoietin
(TPOR), granulocyte colony-stimulating factor 3 (CSF3R), growth hormone (GHR), and …

The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway
functions as a central hub for transmitting signals from more than 50 cytokines, playing a …

The metabotropic glutamate receptors (mGluRs) are neuromodulatory family CG protein
coupled receptors, which assemble as dimers and allosterically couple extracellular ligand …