Nucleic acid-based therapeutics have demonstrated their efficacy in the treatment of various
diseases and vaccine development. Antisense oligonucleotide (ASO) technology exploits a …

As a potent therapeutic agent, small interfering RNA (siRNA) has been exploited to silence
critical genes involved in tumor initiation and progression. However, development of a …

Liposomes are widely used as drug delivery systems and several liposome-based
nanomedicines have been approved for clinical use. Cell penetrating peptides (CPPs) have …

In bacterial biotechnology, instead of producing functional proteins from plasmids, it is often
necessary to deliver functional proteins directly into live cells for genetic manipulation or …

The tumor microenvironment participates in all stages of tumor progression and has
emerged as a promising therapeutic target for cancer therapy. Rapid progress in the field of …

Melittin, a classical antimicrobial peptide, is a highly potent antitumor agent. However, its
significant toxicity seriously hampers its application in tumor therapy. In this study, we …

Glioma, one of the most common aggressive malignancies, has the highest mortality in the
present world. Delivery of nanocarriers from the systemic circulation to the glioma sites …

The roles of microRNAs (miRNAs) in the regulation of metastasis have been widely
recognized in the recent years. Mir-10b antagomir (antagomir-10b) was shown to impede …

To improve the targeting delivery efficiency of anticancer drug to tumor sites, a new strategy
combining cell-permeable peptide (CPP) and ultrasound was reported in this article. In this …

Extracellular synthetic nucleic acids, such as siRNAs, are unable to reach their intended
targets efficiently. Therefore, delivery methods such as cell-penetrating peptides (CPP) …