This thesis describes my contribution to the development of synthetic methods directed at
accessing bicyclic toxic peptides, amatoxins, as well as amatoxin-based bioconjugates for …

One of the greatest challenges in cancer drug therapy is to maximize the effectiveness of the
active ingredient while reducing its systemic adverse effects. Conventional (non-targeted) …

Abstract Cell-penetrating peptides (CPPs) is a class of small molecules peptides which
can penetrate cell membrane. CPPs can efficiently load siRNA, functional proteins, small …

Many of the anticancer compounds discovered through synthesis or bioprospecting activities
are found to be equally toxic to healthy cells and tumors. Consequently, these compounds …

Wojciech Lipiński*, Beata Kolesińska Page 1 2017, 71, 9-10 MODULOWANIE
WŁAŚCIWOŚCI PEPTYDÓW PENETRUJĄCYCH DO KOMÓREK MODULATING …

Therapeutic antibodies are highly versatile macromolecules that can be engineered to bind
and inhibit a target with high specificity. Unfortunately, the cell membrane is impenetrable to …

WO2021007435A1 - Peptide conjugates of cytotoxins as therapeutics - Google Patents
WO2021007435A1 - Peptide conjugates of cytotoxins as therapeutics - Google Patents …

Bacteria, exposed to stress from the environment or competition, release toxins called
bacteriocins. Bacteriocins are classified by their mode of cytotoxicity such as pore former …

the disclosed invention is generally in the field of nucleic acid assemblies and specifically in
the area of nucleic acid assemblies for targeting cargo to cells, tissues, organs, and …

Newly discovered compounds through bioprospecting are screened for cytotoxicity, and
many of them are found to be highly toxic. Because they are often not specifically toxic only …