Recent advances in the drug treatment of inflammatory bowel disease (IBD) have paralleled
our understanding of the pathophysiology of ulcerative colitis and Crohn's disease. Several …

The cytokine interleukin-15 (IL-15) has a key role in promoting survival, proliferation and
activation of natural killer (NK) and CD8+ T cells. Despite its functional similarities to IL-2, IL …

Rely on Rosen's Emergency Medicine for the latest answers on every facet of emergency
medicine practice. For decades, this medical reference book has set the standard in …

The proteasome, a multicatalytic protease, is responsible for the degradation of intracellular
proteins. Stimulation of cells with inflammatory cytokines, such as IFN-γ, leads to the …

Tumor necrosis factor (TNF) was originally described as a protein factor capable of killing
tumor cells in vitro and causing hemorrhagic necrosis of transplantable tumors in mice. 1, 2 …

The resident bacterial flora of the large intestine has become increasingly recognized as an
essential component in the pathogenesis of ulcerative colitis (UC). However, it is still not …

Ulcerative colitis (UC) and Crohn's disease (CD) constitute the two major groups of
idiopathic disorders in inflammatory bowel disease (IBD). Environmental factors, genetic …

Background: Normal sleep is paramount for a healthy lifestyle and high quality of life. Sleep
modulates the immune system and thus affects the course of several chronic inflammatory …

We describe here the immunologic characterization of a new mouse strain, SAMP1/Yit,
which spontaneously develops a chronic intestinal inflammation localized to the terminal …

Purpose Poor sleep quality is associated with adverse health consequences. Sleep
disturbances can impact the immune function and process of inflammation. The relationship …