Simple Summary The mitogen-activated protein kinase/extracellular signal-regulated kinase
(MAPK/ERK) signaling pathway is frequently activated in liver cancer, which is one of the …

Liver regeneration is a highly organized tissue regrowth process and is the most important
reaction of the liver to injury. The overall process of liver regeneration includes three phases …

The therapeutic utility of antibodies and their derivatives is achieved by various means. The
FDA has approved several targeted antibodies that disrupt signaling of various growth factor …

Neoplastic epithelial cells coexist in carcinomas with various non-neoplastic stromal cells,
together creating the tumor microenvironment. There is a growing interest in the cross-talk …

The tumor microenvironment and its contribution to tumorigenesis has been a focal highlight
in recent years. A two-way communication between the tumor and the surrounding …

The incidence and mortality of hepatocellular carcinoma (HCC) have fallen dramatically in
China and elsewhere over the past several decades. Nonetheless, HCC remains a major …

Non-alcoholic liver disease (NAFLD) defines liver abnormalities ranging from simple
steatosis to nonalcoholic steatohepatitis with or without cirrhosis development, occurring in …

Background Type-2 diabetes mellitus (T2DM) is a risk factor for progressive non-alcoholic
fatty liver disease (NAFLD). Drugs commonly prescribed in patients with T2DM may affect …

Metabolic traits of macrophages can be rewired by insulin-like growth factor 2 (IGF2);
however, how IGF2 modulates macrophage cellular dynamics and functionality remains …

Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death worldwide.
Diabetes mellitus, a risk factor for cancer, is also globally endemic. The clinical link between …