The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …

The principles of green chemistry (GC) can be comprehensively implemented in green
synthesis of pharmaceuticals by choosing no solvents or green solvents (preferably water) …

Owing to its efficiency and unique reactivity, mechanochemical processing of bulk solids has
developed into a powerful tool for the synthesis and transformation of various classes of …

Cocrystals are an emerging class of crystalline materials composed of two or more different
molecules in the same crystal lattice that are physically connected by non-ionic and non …

We demonstrate catalytic organic synthesis by Resonant Acoustic Mixing (RAM): a
mechanochemical methodology that does not require bulk solvent or milling media. Using …

We demonstrate the use of a metal surface to directly catalyse copper-catalysed alkyne–
azide click-coupling (CuAAC) reactions under the conditions of Resonant Acoustic Mixing …

Recently, pharmaceutical cocrystals have gained immense interest because of their
potential to tune mechanical, pharmacokinetic, and physicochemical properties of active …

In recent years it is shown that mechanochemical strategies can be beneficial in directed
conversions of organic compounds. Finding new reactions proved difficult, and due to the …

Synthetic mechanochemistry, the use of mechanical force produced by milling, grinding or
extruding, as an activation technique, provides access to chemical entities of all kinds. This …

In the niche area of energetic materials, a balance between energy and safety is extremely
important. To address this “energy–safety contradiction”, energetic cocrystals have been …