Computational chemistry is an essential tool in the pharmaceutical industry. Quantum
computing is a fast evolving technology that promises to completely shift the computational …

Conspectus The quantum chemical cluster approach has been used for modeling enzyme
active sites and reaction mechanisms for more than two decades. In this methodology, a …

The limitations associated with natural enzyme catalysis have triggered the rise of the field of
protein engineering. Traditional rational design was based on the analysis of protein …

l-Isoleucine dioxygenase (IDO) directly catalyzes the C–H bond hydroxylation of several
hydrophobic aliphatic amino acids. However, the ambiguous selectivity of IDO prevents its …

Enzymes can produce high-quality food with low pollution, high function, high acceptability,
and medical aid. However, most enzymes, in their native form, do not meet the industrial …

The ability of lipases to display activity beyond their physiological reactions, so-called
“catalytic promiscuity”, has gained increasing interest in the last two decades as an …

In this study, a Taguchi experimental design was used for optimzing the immobilization of
the lipase Eversa® Transform 2.0 (EVS) onto a hybrid support consisting of chitosan (CHI) …

Prediction of enzymatic stereochemistry is a significant challenge in computational chemistry
because of targeting very small energy gaps in highly complicated macromolecular systems …

The regulation and prohibition of antibiotics used as growth promoters (AGP) in the feed
field are increasing because they cause antimicrobial resistance and drug residue issues …

Abstract β-Galactosidases are crucial carbohydrate-active enzymes that naturally catalyze
the hydrolysis of galactoside bonds in oligo-and disaccharides. These enzymes are …