Nanotechnology-based mRNA vaccines
Abstract mRNA vaccines have emerged as a revolutionary tool to generate rapid and
precise immune responses against infectious diseases and cancers. Compared with …
precise immune responses against infectious diseases and cancers. Compared with …
Targeting cancer with mRNA–lipid nanoparticles: key considerations and future prospects
E Kon, N Ad-El, I Hazan-Halevy… - Nature reviews clinical …, 2023 - nature.com
Harnessing mRNA–lipid nanoparticles (LNPs) to treat patients with cancer has been an
ongoing research area that started before these versatile nanoparticles were successfully …
ongoing research area that started before these versatile nanoparticles were successfully …
mRNA Cancer vaccines: construction and boosting strategies
In late 2020, the US Food and Drug Administration (FDA) approved a lipid-based mRNA
vaccine for the prevention of COVID-19, which has pushed this field to be more closely …
vaccine for the prevention of COVID-19, which has pushed this field to be more closely …
Lipid nanoparticles optimized for targeting and release of nucleic acid
Y Jia, X Wang, L Li, F Li, J Zhang… - Advanced Materials, 2024 - Wiley Online Library
Lipid nanoparticles (LNPs) are currently the most promising clinical nucleic acids drug
delivery vehicles. LNPs prevent the degradation of cargo nucleic acids during blood …
delivery vehicles. LNPs prevent the degradation of cargo nucleic acids during blood …
Lipid nanoparticle-based mRNA delivery systems for cancer immunotherapy
Cancer immunotherapy, which harnesses the power of the immune system, has shown
immense promise in the fight against malignancies. Messenger RNA (mRNA) stands as a …
immense promise in the fight against malignancies. Messenger RNA (mRNA) stands as a …
mRNA vaccines and their delivery strategies: A journey from infectious diseases to cancer
mRNA vaccines have evolved as promising cancer therapies. These vaccines can encode
tumor-allied antigens, thus enabling personalized treatment approaches. They can also …
tumor-allied antigens, thus enabling personalized treatment approaches. They can also …
Considerations on the design of lipid-based mRNA vaccines against cancer
Throughout the last decades, mRNA vaccines have been developed as a cancer
immunotherapeutic and the technology recently gained momentum during the COVID-19 …
immunotherapeutic and the technology recently gained momentum during the COVID-19 …
From structural design to delivery: mRNA therapeutics for cancer immunotherapy
F Zhou, L Huang, S Li, W Yang, F Chen, Z Cai… - …, 2024 - Wiley Online Library
Abstract mRNA therapeutics have emerged as powerful tools for cancer immunotherapy in
accordance with their superiority in expressing all sequence‐known proteins in vivo. In …
accordance with their superiority in expressing all sequence‐known proteins in vivo. In …
The effect of Cryoprotectants and storage conditions on the transfection efficiency, stability, and safety of lipid‐based nanoparticles for mRNA and DNA delivery
KN Kafetzis, N Papalamprou, E McNulty… - Advanced …, 2023 - Wiley Online Library
Lipid‐based nanoparticles have recently shown great promise, establishing themselves as
the gold standard in delivering novel RNA therapeutics. However, research on the effects of …
the gold standard in delivering novel RNA therapeutics. However, research on the effects of …
Scope and challenges of nanoparticle-based mRNA delivery in cancer treatment
Messenger RNA (mRNA) recently emerged as an appealing alternative to treat and prevent
diseases ranging from cancer and Alzheimer's disease to COVID-19 with significant clinical …
diseases ranging from cancer and Alzheimer's disease to COVID-19 with significant clinical …