Nanotechnology-based mRNA vaccines

S Chen, X Huang, Y Xue, E Álvarez-Benedicto… - Nature Reviews …, 2023 - nature.com
Abstract mRNA vaccines have emerged as a revolutionary tool to generate rapid and
precise immune responses against infectious diseases and cancers. Compared with …

Targeting cancer with mRNA–lipid nanoparticles: key considerations and future prospects

E Kon, N Ad-El, I Hazan-Halevy… - Nature reviews clinical …, 2023 - nature.com
Harnessing mRNA–lipid nanoparticles (LNPs) to treat patients with cancer has been an
ongoing research area that started before these versatile nanoparticles were successfully …

mRNA Cancer vaccines: construction and boosting strategies

X Liu, P Huang, R Yang, H Deng - ACS nano, 2023 - ACS Publications
In late 2020, the US Food and Drug Administration (FDA) approved a lipid-based mRNA
vaccine for the prevention of COVID-19, which has pushed this field to be more closely …

Lipid nanoparticles optimized for targeting and release of nucleic acid

Y Jia, X Wang, L Li, F Li, J Zhang… - Advanced Materials, 2024 - Wiley Online Library
Lipid nanoparticles (LNPs) are currently the most promising clinical nucleic acids drug
delivery vehicles. LNPs prevent the degradation of cargo nucleic acids during blood …

Lipid nanoparticle-based mRNA delivery systems for cancer immunotherapy

J Han, J Lim, CPJ Wang, JH Han, HE Shin, SN Kim… - Nano …, 2023 - Springer
Cancer immunotherapy, which harnesses the power of the immune system, has shown
immense promise in the fight against malignancies. Messenger RNA (mRNA) stands as a …

mRNA vaccines and their delivery strategies: A journey from infectious diseases to cancer

RR Malla, M Srilatha, B Farran, GP Nagaraju - Molecular Therapy, 2024 - cell.com
mRNA vaccines have evolved as promising cancer therapies. These vaccines can encode
tumor-allied antigens, thus enabling personalized treatment approaches. They can also …

Considerations on the design of lipid-based mRNA vaccines against cancer

S Meulewaeter, Y Zhang, A Wadhwa, K Fox… - Journal of Molecular …, 2023 - Elsevier
Throughout the last decades, mRNA vaccines have been developed as a cancer
immunotherapeutic and the technology recently gained momentum during the COVID-19 …

From structural design to delivery: mRNA therapeutics for cancer immunotherapy

F Zhou, L Huang, S Li, W Yang, F Chen, Z Cai… - …, 2024 - Wiley Online Library
Abstract mRNA therapeutics have emerged as powerful tools for cancer immunotherapy in
accordance with their superiority in expressing all sequence‐known proteins in vivo. In …

The effect of Cryoprotectants and storage conditions on the transfection efficiency, stability, and safety of lipid‐based nanoparticles for mRNA and DNA delivery

KN Kafetzis, N Papalamprou, E McNulty… - Advanced …, 2023 - Wiley Online Library
Lipid‐based nanoparticles have recently shown great promise, establishing themselves as
the gold standard in delivering novel RNA therapeutics. However, research on the effects of …

Scope and challenges of nanoparticle-based mRNA delivery in cancer treatment

ME Karim, ST Haque, H Al-Busaidi, A Bakhtiar… - Archives of pharmacal …, 2022 - Springer
Messenger RNA (mRNA) recently emerged as an appealing alternative to treat and prevent
diseases ranging from cancer and Alzheimer's disease to COVID-19 with significant clinical …