Membranous nephropathy (MN) is characterized histomorphologically by the presence of
immune deposits in the subepithelial space of the glomerular filtration barrier; its clinical …

In the past decade, kidney disease diagnosed with objective measures of kidney damage
and function has been recognised as a major public health burden. The population …

Background Idiopathic membranous nephropathy is an autoimmune disease. In
approximately 70% of patients, it is associated with autoantibodies against the …

Primary membranous nephropathy (MN) is an autoimmune disease mainly caused by
autoantibodies against the recently discovered podocyte antigens: the M-type …

Idiopathic membranous nephropathy (INM) remains a common cause of the nephrotic
syndrome in adults. The autoimmune nature of IMN was clearly delineated in 2009 with the …

Thrombospondin type 1 domain–containing 7A (THSD7A) is a target antigen identified in
adult membranous nephropathy (MN) along with the major antigen phospholipase A 2 …

Background The complement system is highly activated in primary membranous
nephropathy (MN). Identifying the complement components that damage podocytes has …

Glomerulonephritis (GN) is an important cause of morbidity and mortality in patients of all
ages throughout the world. Because these disorders are relatively rare, it is difficult to …

The discovery in 2009 of the M-type phospholipase A2 receptor (PLA2R) as the primary
target in membranous nephropathy (MN) greatly advanced basic and clinical research …

Autoantibody formation directed against phospholipase A2 receptor (PLA2R) 1 is the
underlying etiology in most cases of primary membranous glomerulopathy. This new …