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39808855&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

(51) Int-Cl- 5,990,276 A 11/1999 Zhang et a1. A01N 43/40(200601) 6,004,933 A 12/1999
Spruce et a1. A61K 31/70(200601) 6,034,134 A 3/2000 Gold et a1. C07H 19/00(2006.01) …

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45818284&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

RE29, 835 E 11, 1978 Witkowski et al. 4,814,477 A 3/1989 Wijnberg et al. 4,957,924 A
9/1990 Beauchamp 5,026,687 A 6, 1991 Yarchoan et al. 5,118,820 A 6, 1992 Hertel …

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Disclosed herein are phosphorothioate nucleotide analogs, such as thiophosphoroamidate
prodrugs and thiophosphates (including (x-thiomonophosphates,(x-thiodiphosphates, and (x …

Disclosed herein are a composition and unit dosage form for the treatment of hepatitis C
virus (HCV) infection comprising GS-7977 and at least one pharmaceutically acceptable …

US8173621B2 - Nucleoside cyclicphosphates - Google Patents US8173621B2 -
Nucleoside cyclicphosphates - Google Patents Nucleoside cyclicphosphates Download …

Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral
diseases. These compounds are inhibitors of RNA-dependent RNA viral replication and are …

Provided herein are compounds, compositions and methods for the treatment of Flaviviridae
infections, including HCV infections. In certain embodiments, compounds and compo sitions …