Genome replication involves dealing with obstacles that can result from DNA damage but
also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA …

ATP-dependent chromatin remodelers are commonly mutated in human cancer. Mammalian
SWI/SNF complexes comprise three conserved multisubunit chromatin remodelers (cBAF …

Genome integrity relies on the accuracy of DNA metabolism, but as appreciated for more
than four decades, transcription enhances mutation and recombination frequencies. More …

Identifying how R-loops are generated is crucial to know how transcription compromises
genome integrity. We show by genome-wide analysis of conditional yeast mutants that the …

Nonscheduled R loops represent a major source of DNA damage and replication stress.
Cells have different ways to prevent R-loop accumulation. One mechanism relies on the …

R-loops are by-products of transcription that must be tightly regulated to maintain genomic
stability and gene expression. Here, we describe a mechanism for the regulation of the R …

DNA replication and RNA transcription compete for the same substrate during S phase.
Cells have evolved several mechanisms to minimize such conflicts. Here, we identify the …

The cell cycle is a crucial biological process that is involved in cell growth, development, and
reproduction. It can be divided into G1, S, G2, and M phases, and each period is closely …

Processing and maturation of precursor RNA species is coupled to RNA polymerase II
transcription. Co‐transcriptional RNA processing helps to ensure efficient and proper …

Different proteins associate with the nascent RNA and the RNA polymerase (RNAP) to
catalyze the transcription cycle and RNA export. If these processes are not properly …