Acute lung injury (ALI) usually causes acute respiratory distress syndrome (ARDS), or even
death in critical ill patients. Immune cell infiltration in inflamed lungs is an important hallmark …

Acute lung injury (ALI) is a disease characterized by pulmonary diffusion dysfunction and its
exacerbation stage is acute respiratory distress syndrome (ARDS), which may develop to …

Inflamed and infected tissue sites are characterised by oxygen and nutrient deprivation. The
cellular adaptations to insufficient oxygenation, hypoxia, are mainly regulated by a family of …

Ym1 and RELMα are established effector molecules closely synonymous with Th2-type
inflammation and associated pathology. Here, we show that whilst largely dependent on IL …

Acute lung injury (ALI) is a condition resulting from direct or indirect lung injury associated
with high mortality and morbidity. The phenotype of macrophages in lung contributes to the …

Background We recently reported histone methyltransferase enhancer of zeste homolog 2
(EZH2) as a key epigenetic regulator that contributes to the dysfunction of innate immune …

Rationale: Serial measurements of alveolar macrophage (AM) transcriptional changes in
patients with acute respiratory distress syndrome (ARDS) could identify cell-specific …

Several members of the matrix metalloproteinase (MMP) family control a range of immune
processes, such as leukocyte influx and chemokine activity. Stromelysin-2 (MMP10) is …

Mechanical ventilation is a life-saving intervention in critically ill patients with respiratory
failure due to acute respiratory distress syndrome (ARDS). Paradoxically, mechanical …

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a disastrous condition,
which can be caused by a wide range of diseases, such as pneumonia, sepsis, traumas …