A number of therapeutic drugs with different structures and mechanisms of action have been
reported to undergo metabolic activation by Phase I or Phase II drug-metabolizing enzymes …

Despite the recent discovery that thalidomide causes limb defects by targeting highly
angiogenic, immature blood vessels, several challenges still remain and new ones have …

Campesterol, a plant sterol in nature, is known to have cholesterol lowering and
anticarcinogenic effects. Since angiogenesis is essential for cancer, it was surmised that an …

Endothelial cells (EC) were extracted through a lectin-based method from bone marrow of
57 patients with active multiple myeloma (MM) and compared with their healthy quiescent …

Antiangiogenesis, eg, inhibition of blood vessel growth, is being investigated as a way to
prevent the growth of tumors and other angiogenesis-dependent diseases. Pharmacological …

Purpose To study the antiangiogenic effect of thalidomide. Patients and Methods The
expression of key angiogenic genes was studied in bone marrow endothelial cells (ECs) of …

The chorioallantoic membrane (CAM) is widely used as a model to examine angiogenesis,
and antiangiogenesis. Its advantages over mammalian systems include low cost, and ease …

Thalidomide remains one of the world's most notorious drugs due to the severe birth defects
it induced in children between 1957 and 1962. Yet, to some this drug is a lifesaver, as it now …

Despite its controversial past, thalidomide is currently under investigation for the treatment of
several disease types, ranging from inflammatory conditions to cancer. The mechanism of …

The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane which
serves as a gas exchange surface and its function is supported by a dense capillary …